Medicinal Chemist Inductive Bio IncMedicinal ChemistSan Francisco, CA$210,000–$250,000 / yearWe are seeking an accomplished Medicinal Chemist to play a key role in building an AI-forward drug discovery platform that impacts all stages of the Design-Make-Test-Analyze cycle, and deploy that platform to dozens of programs across the industry! Through partnerships with CROs, we also offer innovative synthesis approaches, direct-to-dose testing, and cost-effective tier 1 ADME panels that enable initial human PK projection, closing the loop from computational design to experimental validation.
Computational Medicinal Chemist NovartisComputational Medicinal ChemistSan Diego, CaliforniaArtificial Intelligence (AI), Biostatistics, Change Management, Curious Mindset, Data Governance, Data Literacy, Data Quality, Data Science, Data Visualization, Deep Learning, Graph Algorithms, Learning Agility, Machine Learning (ML), Machine Learning Algorithms, Python (Programming Language), Stakeholder Engagement, Statistical Analysis, Time Series Analysis Your Responsibilities Include : Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), structure-based and ligand-based drug design, a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics/pharmacodynamics (PK/PD), and synthetic feasibility.
Director or Associate Director, Medicinal Chemistry Allen SpoldenDirector or Associate Director, Medicinal ChemistryLa Jolla, CaliforniaThe role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
Director, Medicinal Chemistry KardiganDirector, Medicinal ChemistryCalifornia8+ years of pharma/biotech industry drug discovery experience with a strong track record of leading medicinal chemistry across hit identification, hit-to-lead, lead optimization, and development candidate nominations. This role involves providing leadership to cross-functional project teams and effectively collaborating to advance preclinical programs from initiation to delivery of a development candidate.
Staff Scientist II - Medicinal Chemistry Protagonist Therapeutics IncStaff Scientist II - Medicinal ChemistryNewark, CA$135,000–$145,000 / yearThe Company also has a number of preclinical stage drug discovery programs addressing clinically and commercially validated targets including an oral IL-17 peptide antagonist, obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin programs. The base pay range for this position at commencement of employment is expected to be between $135,000 and $145,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
Principal Scientist, Medicinal Chemistry Iambic TherapeuticsPrincipal Scientist, Medicinal ChemistrySan Diego, CaliforniaThe ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
Scientist, Medicinal Chemistry General ProximityScientist, Medicinal ChemistrySan Francisco, CAYour responsibilities will include designing and optimizing first-in-class bifunctional molecules, assessing SAR to inform iterative medicinal chemistry optimization, supervising synthetic efforts with CRO partners, performing and analyzing in cellulo assays, collaborating with our Drug Discovery and IP teams on patent applications, and contributing mechanistic insight on lead drug molecules. Chemical biology techniques including mammalian cell culture, cell-based assays (e.g., cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen); computational chemistry experience also welcomed.
Associate Director, Medicinal Chemistry Project & External Operations Manager CytokineticsAssociate Director, Medicinal Chemistry Project & External Operations ManagerSouth San Francisco, CaliforniaReporting into the Head of Medicinal Chemistry, this individual will lead one or more medicinal chemistry programs while managing the external partners that help execute them, bringing deep medicinal chemistry expertise, strategic project leadership, a thorough understanding of the CRO landscape, and a proven ability to align internal teams and external partners around clear, measurable goals. Cytokinetics is seeking an accomplished medicinal chemist to serve as a Associate Director, Medicinal Chemistry Project and External Operations Manager, combining hands-on scientific leadership of discovery projects with ownership of the strategy, productivity, and quality of our external chemistry partnerships.
Computational Scientist (Medicinal Chemistry) AxiomComputational Scientist (Medicinal Chemistry)San Francisco, CaliforniaThis creates a compounding loop: deeper customer understanding shapes the data we generate; better data improves frontier models, Axiom’s fine-tuned models, and our agentic infrastructure; stronger models and tooling expand the capabilities we can offer; and those capabilities are forward deployed into pharma's drug discovery workflows, where scientists use them to solve the highest value drug discovery problems. Over time, Axiom will invest billions into the world’s largest human datasets across all the major organ systems, paired with an agentic harness that uses this data to predict human drug outcomes dramatically better than animals and phase 1 clinical trials.
Principal Scientist, Medicinal Chemistry Neurocrine Biosciences Inc.Principal Scientist, Medicinal ChemistrySan Diego, CA$130,800–$179,000 / yearThe company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis and uterine fibroids , as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. Your Contributions (include, but are not limited to): Leads projects and initiatives in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification.
Director/Senior Director, Medicinal Chemistry Iambic TherapeuticsDirector/Senior Director, Medicinal ChemistrySan Diego, CaliforniaThe role will entail leading drug discovery projects, coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, ML-driven molecular generation, property predictions, and bioassay data generation. We seek an accomplished and creative medicinal chemistry leader with a proven track record of success in advancing drug discovery programs, setting scientific strategy, and leading cross-functional teams to deliver impact.
Scientist II/Senior Scientist, Medicinal Chemistry General ProximityScientist II/Senior Scientist, Medicinal ChemistrySan Francisco, CAYou will play a central role in molecular design of next generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment. In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization.
Principal Scientist, Medicinal Chemistry Genentech IncPrincipal Scientist, Medicinal ChemistrySouth San Francisco, CA$144,000–$269,100 / yearIn addition to close collaboration with other chemists, the candidate will engage with various functions such as Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety and disease area Biology. You will demonstrate extensive experience and record of accomplishment in one or more of the following areas: medicinal chemistry, methodology/catalysis, total synthesis, chemical biology and physical organic chemistry.
NewMedicinal Chemistry Senior Principal Research Scientist Vertex PharmaceuticalsMedicinal Chemistry Senior Principal Research ScientistSan Diego, CaliforniaThis role will play a critical part in advancing high-quality drug candidates from early discovery through candidate selection, while partnering across multidisciplinary teams to solve complex scientific challenges. D. in Chemistry or related scientific discipline with 6+ years of relevant postdoctoral industry experience; Master’s degree with 9+ years of relevant industry experience; or Bachelor’s degree with 11+ years of relevant industry experience.
Synthetic Chemist II Bureau Veritas SASynthetic Chemist IIPasadena, CA$38–$42 / hourPosition Summary: The Synthetic Chemist II is responsible for design, validation and implementation of synthesis projects in organic synthesis with an emphasis on peptide synthesis, bioconjugation, purification and characterization of compounds of interest. Compensation Range: $38.00-$42.00 per hour (e.g., the job posting is not necessarily reflective of actual compensation that may be earned, and actual compensation is subject to variation due to such factors as location, education, experience, and skillset).
Sr. Scientist/Principal Scientist, Medicinal Chemistry General ProximitySr. Scientist/Principal Scientist, Medicinal ChemistrySan Francisco, CAYou will play a central role in molecular design of next-generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment. In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization.
Sr Associate Scientist I or II, Medicinal Chemistry Iambic TherapeuticsSr Associate Scientist I or II, Medicinal ChemistrySan Diego, CaliforniaThis position offers the opportunity to work within a dynamic, cross-functional environment, collaborating closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning researchers, and software engineers throughout all stages of discovery, from hit identification and lead optimization through candidate selection. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action.
Product Scientist (Computational Chemist) Inductive Bio IncProduct Scientist (Computational Chemist)San Francisco, CA$180,000–$220,000 / yearYou'll also be a thought leader in the development of Inductive's platform, from our predictive models and dose projection tools to Indy, our AI medicinal chemistry assistant, informed by your own experience and what you see working (and not working) on real partner programs. Model in vivo outcomes end to end, from PK/PD/efficacy relationships to projected human dose, helping teams evaluate compounds through a dose-centric lens and reason about property tradeoffs in the context of therapeutic window.
NewQuality Control Analytical Chemist MEDTERIALS INCQuality Control Analytical ChemistSan Carlos, CAFull timeb) Independently perform other analytical assays including Particle Size Analysis, Karl Fischer titration, Differential Scanning Calorimetry, Fluorescence Spectroscopy, following the company’s Test Methods and GMP regulations. Minimum requirements are a Bachelor’s degree (BS) in Chemistry with at least four years GMP pharmaceutical industry experience or a Master’s degree (MS) in Analytical Chemistry or other Chemistry field with at least two years GMP pharmaceutical industry experience.
Postdoctoral Scholar - Research Associate - Chemist University of Southern CaliforniaPostdoctoral Scholar - Research Associate - ChemistLos Angeles, CADr. Yong (Tiger) Zhang's laboratory of the Department of Pharmacology & Pharmaceutical Sciences at USC Mann School of Pharmacy and Pharmaceutical Sciences is seeking a Postdoctoral Scholar - Research Associate to conduct research on protein post-translational modifications, antibody engineering, and preclinical design of chemotherapeutic and immunotherapeutic agents to treat cancer, immune disorders, and infectious diseases. When extending an offer of employment, the University of Southern California considers factors such as (but not limited to) the scope and responsibilities of the position, the candidate's work experience, education/training, key skills, internal peer equity, federal, state, and local laws, contractual stipulations, grant funding, as well as external market and organizational considerations.