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Principal Jobs in Kenmore, MA

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Principal Digital Signal Processing Systems Engineer GCR Professional Services

Cambridge, Massachusetts

Contractor
Quick Apply

As Principal Signal Processing System Engineer you will work directly with customers and program managers to create innovative, multidisciplinary technical solutions, for a broad range of highly-complicated mission needs. You will have hands-on engagement with prototype development, which may include software or firmware coding, test equipment operation and programming, integration and validation, and field tests and customer demonstrations.

30+ days ago

Principal Software Engineer, Payer Portal Athenahealth

Boston, MA

$164,000–$280,000 / year

Based in Boston, MA with a hybrid work arrangement, this role partners with product, architecture, and engineering teams to solve complex revenue cycle challenges using distributed systems, Java, Spring Boot, AWS, Kubernetes, and related technologies. We offer IT solutions and expert services that eliminate the daily hurdles preventing healthcare providers from focusing entirely on their patients — powered by our vision to create a thriving ecosystem that delivers accessible, high-quality, and sustainable healthcare for all.

2 days ago

Principal Systems Engineer The Computer Merchant, Ltd

Woburn, MA

$100–$110 / hour
Contractor

While an hourly range is posted for this position, an eventual hourly rate is determined by a comprehensive salary analysis which considers multiple factors including but not limited to: job-related knowledge, skills and qualifications, education and experience as compared to others in the organization doing substantially similar work, if applicable, and market and business considerations. The SE LRR department delivers cutting-edge expertise in concept development, architectural design, requirements generation and flow-down, modeling and simulation, systems analysis, integration, test, and evaluation of world-class missile defense & sensor systems.

6 days ago

Principal Scientist, Vaccine Virology CSL Seqirus

Waltham, MA

$145,000–$180,000 / year

Techniques may include live-virus and pseudovirus neutralization, infectious-virus culture and titration, plaque and focus-forming assays, TCID50, RT-qPCR, reverse genetics, hemagglutination inhibition (HAI), microneutralization, ELISA, neuraminidase inhibition, and functional antibody assays such as antibody-dependent cellular cytotoxicity (ADCC). Reporting to the Director, Vaccine Virology & Immunology, you will provide scientific leadership and hands-on laboratory expertise to advance seasonal and pandemic influenza vaccines, support existing products, and evaluate new respiratory-virus vaccine opportunities.

8 days ago

Senior Principal Scientist - Remote CSL

Waltham, MA

Remote

$179,000–$212,000 / year

Serves as a subject matter expert for cell and gene therapy and cell-based therapeutic platforms; familiarity with AAV or other viral vectors, baculovirus-based expression systems, insect cell platforms, oligonucleotides, nucleic acid-based therapeutics, or other emerging modalities is a plus. Provides expert technical input and scientific oversight for work conducted with external development and manufacturing partners, including CDMOs, CROs, technology providers, and strategic collaborators; supports technical scope definition, deliverable review, issue investigation, and risk mitigation.

3 days ago

Principal ML Platform Engineer - Remote Appian Corporation

Boston, MA

Remote

$175,000–$325,000 / year

Growth Opportunities: Appian provides a diverse array of growth and development opportunities, including our leadership program tailored for new and aspiring managers, a comprehensive library of specialized department training through Appian University, skills based training, and tuition reimbursement for those aiming to advance their education. Equipped with cutting-edge AI tooling, you will drive the design and delivery of high-complexity engineering solutions, set the technical bar for the team, and lead other engineers towards solutions of real complexity to ensure flawless Enterprise-Grade Orchestration.

30+ days ago

Principal Design Engineer (Mechanical / Mechatronic) System One

Cambridge, MA

Quick Apply

Ten or more years designing precision electromechanical instruments or automated production equipment, with at least five as lead or principal designer on products that reached build and qualification. • Deep practical experience of precision fluid handling: pumps, valves, manifolds, tubing sets, connectors, seals, dead-volume and carryover control.

4 days ago

Principal Program Manager Waters Corporation

Milford, MA

The role serves as the primary business-facing lead for PLM delivery, working closely with stakeholders, IT teams, implementation partners, and senior leaders to ensure PLM capabilities support business priorities, regulatory expectations, operational efficiency, and product data governance. This role combines practical program leadership with strong PLM business process knowledge to deliver scalable solutions across Engineering, Quality, Manufacturing, Regulatory Affairs, Supply Chain, IT, and ERP-connected processes.

30+ days ago

Principal Data Engineer Waters Corporation

Milford, MA

Strong business domain knowledge and experience working with enterprise systems such as SAP (e.g., supply chain data, orders, revenue recognition, pricing), Salesforce (commercial or service processes), with the ability to translate business processes into scalable data solutions. The Principal Data Engineer designs, builds, and enhances robust data pipelines and platforms that support analytics, machine learning, and operational monitoring.

30+ days ago

Principal Pricing Data Engineer Waters Corporation

Milford, MA

Strong business domain knowledge and experience working with enterprise systems such as SAP (e.g., supply chain data, orders, revenue recognition, pricing), Salesforce (commercial operations), and/or Service Excellence domains, with the ability to translate business processes into scalable data solutions. We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance.

30+ days ago

Senior Principal Enterprise Architect Waters Corporation

Milford, MA

As a senior individual contributor with broad influence, the Principal Enterprise Architect will operate at the intersection of business strategy and technology execution—guiding complex architectural decisions, enabling large scale integration programs, and ensuring that near term transformation choices support long term scalability, resilience, and value creation. This role is responsible for shaping Waters’ long term technology direction while playing a critical leadership role in the integration of BD businesses, platforms, and data into the Waters ecosystem.

30+ days ago

Principal Data Engineer (Service) Waters Corporation

Milford, MA

Design and build scalable, reliable data platforms that integrate service delivery data (work orders, cases, products, geography), service team member data (roles, locations, workloads), service revenue and cost data, and proforma P&L information to enable strategic decision-making. You will bring deep technical expertise in service business data domains, operate with a high degree of independence, and contribute to the design and delivery of scalable data platforms that enable strategic decision-making for revenue growth, margin expansion, and operational excellence initiatives targeting $200M+ in EBIT improvement.

30+ days ago

Principal AI Solutions Engineer Waters Corporation

Cambridge, MA

The successful candidate will partner with scientists and engineers across the research organization to identify high-value use cases, configure AI-enabled workflows, and scale approaches that improve productivity, accelerate discovery, and increase innovation yield in domains where AI has not traditionally been applied. Waters Global Research organization advances the analytical instruments, chemistries, and software that laboratories worldwide rely on to characterize molecules with exceptional precision — from biopharmaceuticals to the safety of the food and water supply.

30+ days ago

Research Principal Scientist Waters Corporation

Milford, MA

Design materials with optimized specific applications in reversed-phase, Ion-exchange, HILIC, affinity, mixed-mode, and sample preparation workflows for separations of proteins, monoclonal antibodies, oligonucleotides, peptides, PFAS, and small molecules. Members of Global Research work in highly collaborative cross-functional teams spanning Consumables, Liquid Chromatography, Mass Spectrometry, Clinical, and Informatics technologies to develop novel solutions for complex analytical problems.

30+ days ago

Principal AI Security Analyst Waters Corporation

Milford, MA

We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance. You will lead the security review of AI/ML systems, manage our AI security toolchain, identify emerging threats unique to large-scale models, and build the frameworks that keep our AI infrastructure resilient against adversarial attacks.

30+ days ago

Senior Principal Scientist Waters Corporation

Milford, MA

In addition to leading innovation in material design, you will help advance next-generation manufacturing strategies for Waters particle and bonded-phase production, including scalable and data-rich manufacturing approaches, advanced process characterization, and in-process analytical testing methodologies. As a Senior Principal Scientist within the BioSeparations Portfolio of the Chemistry & Lab Automation Business Unit, you will define and lead the scientific strategy for novel chromatographic materials and enabling chemistries for biologics ranging from oligonucleotides, viral vectors, and mRNA to proteins, peptides, and gene-editing therapeutics.

30+ days ago

Principal Agentic Engineer Jobot

Boston, MA

$190,000–$250,000 / year
Quick Apply

This organization takes Public Health and Patient Outcome improvements to the next level, combining the latest and greatest technologies available today to tackle the challenges faced by clinical researchers, patients, and healthcare providers nationwide. Team Health & Culture: Create an inclusive, accountable, and collaborative engineering culture where people feel empowered to make decisions, understand how their work contributes to the broader mission, and are motivated by the real-world impact of the products they build.

3 days ago

Principal Software Engineer - Storage Engine Elastic

Boston, MA

Remote

This globally distributed, fully remote team of experienced engineers develops core storage and query technologies for observability workloads, including improving storage efficiency, advancing ES|QL query processing and performance, and optimizing data layouts for object storage. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

30+ days ago

Principal Java Engineer - Distributed Systems, Serverless Elastic

Boston, MA

Leveraging your deep distributed systems expertise to design, build, and operate core pieces of our next-generation Serverless Elasticsearch offering, directly impacting the experience of customers worldwide. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

30+ days ago

Principal Software Engineer I - Serverless - Platform Control Plane Elastic

Boston, MA

8+ years building software, including setting technical direction for complex distributed systems running production at scale (Staff or Principal level, or equivalent scope). By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

30+ days ago

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Principal Jobs in Kenmore, MA

Principal Digital Signal Processing Systems Engineer GCR Professional Services

Principal Software Engineer, Payer Portal Athenahealth

Principal Systems Engineer The Computer Merchant, Ltd

Principal Scientist, Vaccine Virology CSL Seqirus

Senior Principal Scientist - Remote CSL

Principal ML Platform Engineer - Remote Appian Corporation

Principal Design Engineer (Mechanical / Mechatronic) System One

Principal Program Manager Waters Corporation

Principal Data Engineer Waters Corporation

Principal Pricing Data Engineer Waters Corporation

Senior Principal Enterprise Architect Waters Corporation

Principal Data Engineer (Service) Waters Corporation

Principal AI Solutions Engineer Waters Corporation

Research Principal Scientist Waters Corporation

Principal AI Security Analyst Waters Corporation

Senior Principal Scientist Waters Corporation

Principal Agentic Engineer Jobot

Principal Software Engineer - Storage Engine Elastic

Principal Java Engineer - Distributed Systems, Serverless Elastic

Principal Software Engineer I - Serverless - Platform Control Plane Elastic

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