NewProgram Manager, Principal - Secret DCS CorporationProgram Manager, Principal - SecretBedford, MA$123,639–$199,000 / yearIn this Advisory and Assistance Services (A&AS) role, you will provide expert-level support to Department of Defense (DoD) programs by assisting government leadership with decision-making, planning, and execution throughout the acquisition lifecycle. DCS has an exciting opportunity for a Program Manager SME (Principal) supporting the Air Force Life Cycle Management Center/PEO Electronic Systems Directorate (AFLCMC/HB) within the HBU Force Protection Division at Hanscom AFB.
Principal Product Manager - EAMC ImprivataPrincipal Product Manager - EAMCWaltham, MA$180,600–$191,100 / yearAt Imprivata, we deliver unified access and security management programs that eliminate friction, empowering healthcare and mission-critical organizations to work smarter, faster, and more securely. The Principal Product Manager is responsible for Imprivata's Enterprise Access Management Cloud offering and the overall success of that business area, including adoption and growth.
Resiliency Associate/Principal Planner Central Mass Regional Planning CommissionResiliency Associate/Principal PlannerWorcester, MA$52,538–$80,000 / yearTypical duties may include: · Contribute to or lead the development of a wide variety of planning initiatives and regional and municipal support activities, including climate resiliency initiatives, energy efficiency initiatives, hazard mitigation planning, open space and recreation planning, trail mapping, climate pollution reduction planning, and related efforts. The position will support open space and recreation plans, hazard mitigation plans, climate pollution reduction, energy reduction, resiliency planning, trail mapping, and related municipal and regional planning initiatives, with opportunities to contribute to comprehensive master plans, economic development plans, housing plans, and similar efforts.
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development 3316 Takeda Development Center AmericasSenior/Principal Scientist, Analytical Cell Line Engineering and Bioassay DevelopmentLexington, Massachusetts$154,400–$242,550 / yearHow you will contribute: Lead the design, generation, characterization, and lifecycle management of stable mammalian analytical cell lines expressing targets of interest, receptor systems, or reporter constructs to support potency and functional bioassays. Operating at the interface between Discovery, Global Biologics, Analytical Development, and late-stage potency teams, this role translates product mechanism of action into scientifically sound, phase-appropriate cell line and assay strategies.
Process Development Principal Scientist AmgenProcess Development Principal ScientistMassachusettsIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. In this vital role as an Attribute Sciences team lead and group lead you will work to provide strategic analytical leadership to teams developing commercial manufacturing processes for synthetic and hybrid molecules and collaborate closely with Drug Substance, Drug Product and Product Quality colleague.
Principal Program Scheduler Torch TechnologiesPrincipal Program SchedulerHanscom AFB, Massachusetts$145,000–$160,000 / yearBy enabling aircrews to electronically receive and process tasking orders, intelligence inputs, target coordinates, and mission‑critical flight and weapons data, MPS enhances combat effectiveness, increases sortie generation rates, and improves aircrew readiness and survivability across the Combat Air Forces (CAF) and Mobility Air Forces (MAF). Several factors can influence the salary for a position including but not limited to, Federal Government contract labor categories and contract wage rates, geographic location, business considerations, scope and responsibilities of the position, local or other applicable market conditions, and internal equity.
Positively Partners Principal Consultant, Organizational Effectiveness Positively PartnersPositively Partners Principal Consultant, Organizational EffectivenessSouth Attleboro, Fully Remote (US)RemoteMany consulting engagements occur alongside broader partnerships delivered through PositivelyHR, our subscription-based outsourced HR service providing embedded HR leadership, systems, compliance, payroll administration, and day-to-day people support. As a Principal Consultant, Organizational Effectiveness, you will serve as a trusted advisor to nonprofit executives, partnering with leaders to solve complex organizational challenges and build stronger, healthier workplaces.
Principal RA Associate Devices Fresenius Medical CarePrincipal RA Associate DevicesWaltham, MassachusettsResponsible for preparing FDA submissions necessary for new product approvals/clearances which include Premarket norifictoins-510(k)s, Premarket Approval Applications (PMAs) and supplements, Investigational Device Exemptions (IDEs) submissions. Serves as the primary regulatory resource for change to and prioritization of projects, resource assignment and efficient management of the development and change processes.
Principal Thermal Mechanical Engineer FlexPrincipal Thermal Mechanical EngineerLittleton, MassachusettsThe Principal Mechanical Engineer will provide technical leadership, mentorship, and hands-on expertise in mechanical design, fluid dynamics, and heat transfer but also work closely with customers in communicating the art of the possible with JetCool technology and building a strong customer relationship on a technical level. Lead the initial design, analysis, and optimization of complex fluid systems from concept initial CAD to final detailed CAD and drawing for liquid cooling, including cold plates, pumps, fluids, tubing, and heat exchangers, for the latest computer processing chipsets.
Senior/Principal Scientist Cell Based Potency Assay 3316 Takeda Development Center AmericasSenior/Principal Scientist Cell Based Potency AssayLexington, MassachusettsD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearThe embedded software operates under tight real-time, safety-critical constraints, directly driving electromechanical subsystems where milliseconds and failure modes matter, and you will be in the lab working through hardware-software integration issues alongside electrical and mechanical engineers, not just reviewing designs from a distance. This is a hands-on role: you will be building the embedded software for our surgical stapling platform yourself, writing code, integrating drivers, and debugging at the hardware level, while also owning the technical architecture and setting the long-term direction for embedded systems across the platform.
Principal C# Engineer / Technical Lead Integrated Computer SolutionsPrincipal C# Engineer / Technical LeadWaltham, MassachusettsICS blends the art of visual design and agile engineering to help our clients develop their products into devices that delight in a wide range of technologies. As a Principal Engineer / Technical Lead, you will be responsible for the design, development, and testing of software products in the Microsoft stack in the MedTech and industrial space.
Principal Application Scientist Revvity, Inc.Principal Application ScientistHopkinton, MA$120,000–$155,000 / yearWorking with key commercial entities, you will craft automation methods & workflows that will be disseminated globally, allowing Revvity specialist to support internal sales specialists and customers with novel and well annotated automation methods, allowing Revvity to continue to lead the field. The individual is expected to support the global Revvity automation business by expanding instrument capabilities, working as necessary with technical support to troubleshoot complex customer issues, and providing training and marketing material for new application capabilities that will be used to support the sales of automation instruments globally.
Principal Scientist SanofiPrincipal ScientistWaltham, MA$122.25–$176.58 / hourThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Main responsibilities: Lead scale-up activities from bench scale to pilot scale (200L-2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Principal Specialist, Quality Assurance Cardinal HealthPrincipal Specialist, Quality AssuranceMansfield, MassachusettsCross-functional Collaboration: Leads complex cross-functional projects to identify root causes of significant quality issues, educates stakeholders on quality requirements, and develops sustainable solutions to minimize future risks. The Principal Specialist, Quality Assurance, is a highly experienced individual contributor who applies advanced knowledge of quality assurance concepts and technical capabilities to drive uncompromised laboratory integrity and minimize risks.
Principal Software Security Engineer Harvard Partners Trusted IT AdvisorsPrincipal Software Security EngineerJohnston, Rhode Island$80–$90Partner with business line and architects during initial project stages to ensure the accuracy of requirements and provide critical input and direction from a technology perspective. As the Principal Software Security Engineer you will be responsible for designing, building, and supporting our identity applications and APIs, primarily using Java.
Principal Network Engineer Sun Life FinancialPrincipal Network EngineerWellesley Hills, MA$70,300–$105,500 / yearAdvanced proficiency in Infrastructure as Code (IaC) using Terraform or AWS CloudFormation, paired with experience utilizing Generative AI developer tools (e.g., Amazon Q, Amazon Bedrock, or AI coding assistants) to accelerate code generation, automate network compliance validation, and scale CI/CD network deployment pipelines. The ideal candidate will have strong experience designing, implementing, and supporting enterprise network infrastructure, with expertise in Cisco routing and switching technologies, WatchGuard firewalls, AWS networking services, Infrastructure as Code, and utilizing Generative Developer tools.
Principal Design Quality Engineer I Nova BiomedicalPrincipal Design Quality Engineer IWaltham, MA$120,000–$160,000 / yearNova Biomedical is proud to be a global leader in osmolality testing and biotechnology and in vitro diagnostic (IVD) instrumentation, dedicated to advancing patient care and scientific discovery with a legacy that continues to shape the future of life sciences. With headquarters in Norwood and Waltham, Massachusetts, and a global team of nearly 2,000 employees, we’re building a collaborative, empowered culture grounded in shared values: Customer Centricity, Ingenuity, Ownership & Accountability, Collaboration, and Integrity .
Principal Clinical Content- Physician - Uptodate, Physician Editor, Neurology Wolters KluwerPrincipal Clinical Content- Physician - Uptodate, Physician Editor, NeurologyWaltham, MARemote$173,500–$310,000 / yearUpToDate editors work closely with outside authors, section editors, editors-in-chief, and peer reviewers to ensure the material is accurate and free of bias. In the remaining 10 to 20% time, Physician Editors should continue patient care activities, using their clinical experience to help ensure the content of the program is maximally useful at the point of care.
Associate Principal- Commercial Strategy Trinity PartnersAssociate Principal- Commercial StrategyWaltham, Massachusetts$156,000–$234,000 / yearTrinity’s salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. Associate Principals have unique opportunities to manage daily client interactions with full oversight over project teams – client management, project management, employee management, budget and financial management, and more.