100 Results for

Principal Jobs in Worcester, MA

Jobs

New!

Bedford, MA3 days ago

$123,639–$145,000 Per Year

Command, Control, Communications, and Battle Management (C3BM) has been tasked with delivering an integrated Department of the Air Force (DAF) Battle Network providing resilient decision advantage and enabling the USAF, USSF, Joint, and Coalition Force to win against the pacing challenge. C3BM’s main efforts are Architecture and Systems Engineering (ASE), Operational Response Team (ORT), and multiple mission integration teams such as Air, Maritime and multiple acquisitions consisting of both the Advanced Battle Management System (ABMS) and Space.

Lancaster, MA30+ days ago

Must assist in enforcing the school code of conduct, testing and assessment programs, preparation of student and class schedules, assist all custodial, cafeteria, and other support services, assist in all curriculum matters. Assist parents through prompt communication and support for the purpose of impacting and improving students' academic performance.

Natick, Massachusetts30+ days ago

$200,000–$300,000 Per Year

Lancaster, MA30+ days ago

The job of Principal - Elementary was estabished for the purpose/s of providing support to the instructional process with specific responsibility for directing overall site operations, services and staff at an elementary school; providing information and serving as a resource to others; enforcing established policies and regulatory requirements; coordinating school activities and addressing issues, situations and/or problems that arise on campus or with enrolled students. Minimum requirements: Master's degree, or higher in job related area, two years of administrative experience as well as five (5) years as a teacher preferred.

New!

Waltham, MA4 days ago

$155,000–$190,000 Per Year

Nova Biomedical is proud to be a global leader in osmolality testing and biotechnology and in vitro diagnostic (IVD) instrumentation, dedicated to advancing patient care and scientific discovery with a legacy that continues to shape the future of life sciences. Lead system-level analysis and risk mitigation strategies related to battery thermal behavior and heat dissipation, including charging scenarios, environmental extremes, and long-term reliability to ensure patient safety and regulatory compliance.

New!

Waltham, MA4 days ago

$120,000–$160,000 Per Year

Nova Biomedical is proud to be a global leader in osmolality testing and biotechnology and in vitro diagnostic (IVD) instrumentation, dedicated to advancing patient care and scientific discovery with a legacy that continues to shape the future of life sciences. With headquarters in Norwood and Waltham, Massachusetts, and a global team of nearly 2,000 employees, we’re building a collaborative, empowered culture grounded in shared values: Customer Centricity, Ingenuity, Ownership & Accountability, Collaboration, and Integrity.

Waltham, MA30+ days ago

Full-time

Working knowledge of advanced consulting methodologies, tools, and techniques – with focus on: leveraging AI, LLMs, and life sciences real-world data, for purposes such as patient finding, HCP segmentation, and other applications of advanced analytics, optimization of omnichannel plans, marketing mix, performance analytics and reporting related activities. 10+ years as a top performer within a top-tier biopharmaceutical / pharmaceutical strategy consulting firm serving industry leading clients and/or relevant experience with advanced analytics, omnichannel measurement, marketing analytics, and/or technology-enabled solutions within pharma and biotech.

Bedford / Hanscom AFB, Massachusetts30+ days ago

Bedford / Hanscom AFB, Massachusetts20 days ago

$140,000–$150,000 Per Year

The Air Force Program Execution Office for PEO Electronic Systems (ES) has the collective Air Force Materiel Command (AFMC) mission responsibility to manage and execute the modernization, development, testing, production, fielding, and sustainment of the PEO Digital portfolio, which includes over 130 programs for the United States Air Force (USAF) and foreign allies. Astrion has an exciting opportunity for a PRINCIPAL LOGISTICS MANAGERproviding support to the Air Force Life Cycle Management Center (AFLCMC), PEO Electronic Systems (ES) located at HANSCOM AFB, MA.

Bedford / Hanscom AFB, Massachusetts30+ days ago

Astrion has an exciting opportunity for a Principal Data Links and Communications Engineerfor the EPASS Cyber and Networks Directorate (EPASS HN II) contract, supporting the Aerial Networks Division (AFLCMC/HNA) located at Hanscom AFB, MA. Support defining and documenting a set of Combat Net Radio (CNR) networking parameter configurations to provide the best balance between flexible implementation of capability and implementation impact on both existing and emerging weapon systems.

Waltham, MA14 days ago

We are looking for an experienced researcher to join our team as Principal Research Associate/Associate Scientist in the Molecular Assembly team, supporting our novel target identification and validation workflow in house. Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.

Cambridge Crossing, MA30+ days ago

$156,180–$189,252 Per Year

Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development is highly desired. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects.

Devens, MA30+ days ago

$124,590–$151,000 Per Year

Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Build effective relationships/partnerships and work cross-functionally with internal and external stakeholders to implement novel integrated automated systems to streamline execution and analysis of cell therapy assays.

Cambridge Crossing, MA30+ days ago

$166,770–$202,086 Per Year

Hands on experience analyzing and integrating high-dimensional molecular datasets such as multi-omics (RNA-seq, ATAC-seq, proteomics, ChIP-seq/CUT&RUN ), single cell (CITE-seq, scATAC-seq, perturb-seq) and spatial profiling (Visium, GeoMx, CosMX ). We seek a creative and passionate computational scientist to join the Neuroscience, Immunology, and Cardiovascular (NIC) discovery team within Informatics and Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development.

Bedford / Hanscom AFB, Massachusetts30+ days ago

$140,000–$150,000 Per Year

C3BM’s main efforts are Architecture and Systems Engineering (ASE), Operational Response Team (ORT), and multiple mission integration teams such as Air, Maritime and multiple acquisitions consisting of both the Advanced Battle Management System (ABMS) and Space. Command, Control, Communications, and Battle Management (C3BM) has been tasked with delivering an integrated Department of the Air Force (DAF) Battle Network providing resilient decision advantage and enabling the USAF, USSF, Joint, and Coalition Force to win against the pacing challenge.

Bedford / Hanscom AFB, Massachusetts23 days ago

$150,000–$180,000 Per Year

Prepare technical documentation to define and recommend system/subsystem characteristics; produce management reports and technical presentations for planning, implementation, and corrective actions. Conduct program portfolio reviews to evaluate/recommend alternative plans, improve engineering processes, sustain program baselines, and validate system-level performance in accordance with specifications.

Bedford / Hanscom AFB, Massachusetts13 days ago

The BMC Remedy Architect Principal position is located at Hanscom AFB, MA and focuses on providing acquisition program management support for Cyberspace Security and Control System (CSCS) programs. Defines, writes, and delivers specifications, user guides, and architecture and methodology as appropriate to meet project deadlines.

Cumberland, RI30+ days ago

$120

This hybrid role bridges traditional Microsoft Information Protection and compliance tools with modern AI-centric data security practices, including encryption for LLM pipelines, secure vector stores, and legacy data remediation. - Looking for experience with Snowflake, Microsoft Defender, DLP tools, Azure Purview and with a data engineering background that is operating in an oversight role or assisting a larger organization using those tools.

Johnston, Rhode Island29 days ago

$80–$90

Some of our practices include:• Program/Project Management and "PMO as a Service"• IT Assessments• Business Continuity/Disaster Recovery• Optimized Infrastructure• Concierge Managed Services• Data Center Strategy, Transformation, and Migration• Cloud Management Programs• Security Assessments and Remediation• Staffing, technical & tacticalWorking with the client’s staff, vendors, and consultants, we deliver supportive and collaborative engagements where direct dialog, simplified reporting, productive meetings, and clear responsibility and accountability encourage active participation resulting in consensus-based business outcomes. About Harvard Partners Trusted IT Advisors:Harvard Partners is a management consulting firm focused on helping companies more effectively leverage their IT investment.

Waltham, MA26 days ago

Full-time

This individual, with some supervision, will independently drive synthesis, purification, formulation, and analytical characterization of modified oligonucleotides to support discovery and early development programs. In our fast-paced startup environment, this role requires strong technical skills, hands-on execution, problem-solving creativity, and a willingness to take ownership of processes and infrastructure as we scale.

Waltham, MA13 days ago

$137,000–$220,000

In accordance with state and local pay transparency laws—including those in California, Colorado, Massachusetts, New York, New Jersey, and others—we disclose salary ranges in all job postings and provide additional information upon request. In this role, you will partner closely with Platform, Security, Compliance, and Engineering teams to enable reliable, audit-ready cloud environments while balancing velocity, security, and operational excellence.

Westborough, MA30+ days ago

The major responsibilities of the position include guiding and overseeing product innovation activities (organic and inorganic), translating business strategies into product concepts, defining strategies for product specifications and design inputs, conceptual product design, and development/validation of preliminary business cases. Olympus Corporation of the Americas, a wholly owned subsidiary of Olympus Corporation, is headquartered in Center Valley, Pennsylvania, USA, and employs more than 5,200 employees throughout locations in North and South America.

Waltham, MA30+ days ago

$170,000–$200,000

This role is ideal for an engineer who thrives at the intersection of analog, highspeed digital, mixed signal, and system integration, and who enjoys solving ambiguous problems by turning constraints into clear, robust designs .   . As part of a small, highly collaborative engineering organization, you will work closely with other senior engineers to define system architectures, lead tradeoff analyses, and drive critical technical decisions.

Medway, MA30+ days ago

Work with the Global Planning Functions to develop short and long term global strategies to ensure that we balance service and inventory tradeoffs while maintaining healthy partnerships, effective supply flow and a globally leveraged buying process . Develops, implements, and executes a globally aligned inventory management strategy that drives highly visible customer service levels, logistical flows, and effective turns which allow for flexibility and marketplace health.

Marlborough, MA30+ days ago

Analyze and review project data, correct errors, and report results for multiple projects to support research and development primarily focused on oligonucleotides. Subject matter expert analytical chemistry knowledge including theory and application of three or more chromatographic and spectroscopic techniques for identification, purity, and assay of various analytes .

Marlborough, MA30+ days ago

Review analytical data and reported results for completeness and accurately transfer technical information into written format using tables, graphs, text, or other means to present data and results clearly and completely. The Principal Technical Writer is responsible for originating and reviewing analytical documentation in accordance with SOPs in support of analytical deliverables across multiple projects.

Tewksbury, MA30+ days ago

ACTIVE US Secret Clearance REQUIREDDesired Skill Sets:* Experience using test equipment, software installations, and integrating or regression testing systems with certifications in CompTIA Network+ and or CompTIA Security+.* Experience with MATLAB, Linux Operating Systems (Linux Red Hat), Unix, Perl, C/C++, and Shell scripting for performing integration, verification and test analysis, integrating and configuring electronics/network routers, and installing/debugging software.* Experience with agile and DevSecOps processes, implement (or maintain) agile methodologies, participating in daily team standup meetings, sprint reviews, program Increment (PI) Planning meetings, retrospectives, and agile tooling such as JIRA and Confluence, and support execution of the team"s backlog including performance analysis and issue investigation.*

BEDFORD, MA30+ days ago

Full-time

Required QualificationsPhD in Immunology, Protein Engineering, Biochemistry, Molecular Biology, or a related field, with 7+ years of relevant industry experience in biologics or protein therapeutics discovery (4+ years for Senior Scientist level). The successful candidate will combine deep expertise in protein engineering, antibody and multispecific formats, and immuno-oncology biology with strong scientific leadership and hands-on execution.

BEDFORD, MA30+ days ago

Full-time

Founded in 2003 by a team of Taiwanese-American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung. The successful candidate will play a critical role in shaping therapeutic concepts and leading programs from early-stage discovery through IND-enabling studies, with significant influence over scientific strategy and key program-level decisions.

TEWKSBURY, MA30+ days ago

Provide technical direction across various stages of missile operations, including the disposition of field return assets, complex assembly and disassembly issues, and ensuring mission readiness for flight tests. _As part of our commitment to maintaining a secure hiring process, candidates may be asked to attend select steps of the interview process in-person at one of our office locations, regardless of whether the role is designated as on-site, hybrid or remote._.

Hanscom AFB, Massachusetts21 days ago

The Air Force Program Execution Office for PEO Electronic Systems (ES) has the collective Air Force Materiel Command (AFMC) mission responsibility to manage and execute the modernization, development, testing, production, fielding, and sustainment of the PEO Digital portfolio, which includes over 130 programs for the United States Air Force (USAF) and foreign allies. Please Note: Final compensation for this position will be determined by various factors such as the Federal Government contract labor categories and contract wage rates, relevant work experience, specific skills and competencies, geographic location, education, and certifications.

Hanscom AFB, Massachusetts30 days ago

Hanscom AFB, Massachusetts30+ days ago

Massachusetts30+ days ago

Mansfield, Massachusetts22 days ago

Cross-functional Collaboration: Leads complex cross-functional projects to identify root causes of significant quality issues, educates stakeholders on quality requirements, and develops sustainable solutions to minimize future risks. The Principal Specialist, Quality Assurance, is a highly experienced individual contributor who applies advanced knowledge of quality assurance concepts and technical capabilities to drive uncompromised laboratory integrity and minimize risks.

Waltham, MA12 days ago

$135,000–$145,000 Per Year

The position requires ownership of the accounting processes for multiple international entities, strong technical accounting expertise, attention to detail, problem-solving skills, and the ability to strategically collaborate cross-functionally. The day-to-day functions include journal entries, month-end close reconciliations, accounts payable review, cash management and local tax filings.

Sutton, MA14 days ago

$120,000–$160,000 Per Year

Our engineering organization operates across North America, Asia, and EMEA, combining advanced simulation and ISTA-certified testing to deliver system-level packaging platforms for enterprise server racks, AI compute infrastructure, and mission-critical data center hardware. The Senior / Principal Design Engineer – Enterprise Server Rack & AI Infrastructure Packaging is a senior technical leadership role responsible for owning the architecture and evolution of packaging systems used to deploy some of the world’s most valuable compute infrastructure.

Marlborough, MA30+ days ago

Additionally, you’ll generate supplier performance metrics to support decision-making, apply metrology and statistical tools to solve problems, and travel internationally to conduct audits, quality reviews, and onboard new suppliers. Additionally, they should be able to stand, walk, reach with hands and arms, stoop, kneel, crouch, and be prepared to engage in domestic and international travel as required by the position.

Johnston, RI30+ days ago

$127,520–$191,280 Per Year

Infusing quality of service characteristics, such as scalability, manageability and maintainability, into distributed service-based framework to create or expand business or technical capabilities. + Hand on experience integrating Calypso with financial market utilities such as DTCC SDR, FedWire, Bloomberg, AcadiaSoft, TriResolve and with market data sources, market and credit risk platforms.

Marlborough, MA30+ days ago

You will collaborate with key stakeholders, including Regulatory Affairs, Quality Assurance, Supplier Quality Assurance, Engineering Services, Supply Chain Leadership, Research & Development, and Information Services, to lead strategic initiatives that enhance operational success and worldwide growth. + Provide expertise in enterprise technologies such as: Enterprise Quality Management (EQMS), Enterprise Document Management (EDMS), Product Lifecycle Management (PLM), fostering alignment across business functions and geographies.

Westwood, MA30+ days ago

$145,000–$170,000 Per Year

Maynard, MA30+ days ago

For quota-based incentive pay, Cisco typically pays as follows: 75% of incentive target for each 1% of revenue attainment up to 50% of quota; 1.5% of incentive target for each 1% of attainment between 50% and 75%; 1% of incentive target for each 1% of attainment between 75% and 100%; and once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. Join our team at Acacia, where we design advanced optical transceivers for high-speed fiber optic transmission in data centers and telecommunication networks.

Boxborough, MA30+ days ago

For quota-based incentive pay, Cisco typically pays as follows: 75% of incentive target for each 1% of revenue attainment up to 50% of quota; 1.5% of incentive target for each 1% of attainment between 50% and 75%; 1% of incentive target for each 1% of attainment between 75% and 100%; and once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. + Collaborate with multi-functional teams, including Silicon One architects, software engineers and senior partners to ensure the alignment of Silicon One software initiatives and development work with business objectives.

Marlborough, MA30+ days ago

Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, education, business needs and market demand. In this role, you’ll be responsible for ensuring compliance with global regulations, championing advanced quality tools, and driving continuous improvement across our divisional and global operations.

Waltham, MA30+ days ago

$141,400–$215,400 Per Year

As a Senior Principal Compensation Partner you will be responsible for working closely with key stakeholders in understanding the business, identifying compensation needs and priorities, as well as proactively providing compensation solutions and insights. Pega is committed to continuing to be a best place to work for talent, and this role will help drive proactive compensation solutions and forward-thinking strategies to attract, retain and develop top talent across the globe.

Foxborough, MA14 days ago

$150,000–$210,000 Per Year

This role is ideal for a senior automation professional who enjoys solving technically complex problems, guiding project teams, and working directly with life sciences clients in highly regulated environments. We partner with clients across life sciences, food and beverage, power, specialty chemicals, and consumer products to improve throughput, accelerate technology adoption, contextualize data, and strengthen process and product quality.

Waltham, MA30+ days ago

Best number to reach you: Work authorization/Visa Status: Current Location: Current Compensation: Expected Compensation: Best time to call you: Waiting for your earliest response. This project aims to rebuild the solution to create a more modular architecture, ensuring scalability and long-term maintainability.

Waltham, MA30+ days ago

Play a leadership role in identifying areas of opportunity — e.g., using ML/AI to unlock new revenue streams (e.g., rapid quoting for new manufacturing modalities, generative design for customers), reduce cost (e.g., automated quality inspection), or optimize efficiency (e.g., 3D-geometry classification, defect detection, generating manufacturing ready models). Stay ahead of industry developments in ML, AI, generative AI, 2D/3D modeling and manufacturing tech; translate insights into the improvement of internal best practices, tooling, frameworks, model governance, data pipelines, and operationalization.

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Principal Jobs in Worcester, MA

Jobs

Software Engineer, PrincipalDCS Corporation

Assistant Principal (2026-2027 School Year)Rutherford County Schools

Principal Scientist (M.D. or D.O.)Exponent Inc.

Pleasant Hill Elementary - PrincipalCumberland County School District

Principal Systems Engineer - POC DevicesNova Biomedical

Principal Design Quality Engineer INova Biomedical

Principal, AnalyticsTrinity Partners, LLC

Principal Software EngineerAstrion

Principal Logistics ManagerAstrion

Principal Data Links and Communications EngineerAstrion

Principal Research Associate/Associate Scientist, Molecular AssemblyTScan Therapeutics

Principal Scientist, In Vivo Pharmacology, Oncology Discovery BiologyBristol Myers Squibb

Principal Scientist, QC Assay Automation, Cell Therapy in Devens, MABristol Myers Squibb

Principal Scientist Computational BiologyBristol Myers Squibb

Principal Systems EngineerAstrion

Principal Network EngineerAstrion

BMC Remedy Application Developer PrincipalAstrion

Data Security Principal ArchitectLancesoft

Principal Software Security EngineerHarvard Partners Trusted IT Advisors

Principal Research Associate - Oligonucleotide ChemistryAlloy Therapeutics

Principal DevOps EngineerEvolv Technologies Inc.

Sr Principal R&D EngineerOlympus Corporation of the Americas

Principal Electrical EngineerEvolv Technologies Inc.

Principal Inventory Program ManagerCoyote Technical & Executive Sourcing

Analytical Development Principal ScientistNITTO DENKO Avecia

Principal Technical WriterNITTO DENKO Avecia

Principal Systems Engineer - CLEARANCE REQUIREDBelcan

Principal/ Senior Scientist – T Cell Engager & Multispecific Protein EngineeringPharmaEssentia U.S.A.

(Senior) Principal Scientist, Cell TherapyPharmaEssentia U.S.A.

Principal Reliability EngineerRTX Corporation

Principal Logistics ManagerOdyssey Systems Consulting Group, Ltd.

Principal Systems EngineerOdyssey Systems Consulting Group, Ltd.

Principal Software EngineerOdyssey Systems Consulting Group, Ltd.

Principal Software Development Engineer – Compiler & ML AccelerationAdvanced Micro Devices, Inc

Principal Specialist, Quality AssuranceCardinal Health

Principal AccountantImprivata

Principal / Senior Design Engineer – Enterprise Server Rack & AI Infrastructure PackagingUN1F1ED2 Global Packaging Group

Principal Electrical Supplier Quality EngineerHologic

Principal Software Engineer - Calypso (Hybrid Role)Citizens

Principal Solutions Analyst, Global IT Quality SolutionsHologic

Principal DLP Engineer - MS PurviewCitizens

Principal DSP Engineer – Coherent Optical Transmission Systems - AcaciaCisco

Principal Engineer - Silicon One SoftwareCisco

Principal Quality Assurance EngineerHologic

Senior Principal Compensation PartnerPegasystems

Principal Automation EngineerStellix Global Services

Principal Embedded DeveloperSyntricate Technologies Inc

Senior Principal, ML/AIXometry

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