Our laboratory is interested in a wide variety of model systems and experimental approaches, including biochemistry, molecular biology, structural biology, animal models, genomics, proteomics, bioinformatics, and computational biology to uncover how signaling pathways control gene expression programs, spanning multiple interconnected areas: (1) signaling by NAD+ and steroid hormones; (2) ADP-ribosylation and the PARP enzymes that catalyze this modification in transcription, translation, chromatin dynamics, and RNA biology; (3) enhancer function and enhancer RNA regulation in gene activation; (4) RNA-based mechanisms in nuclear signaling and gene regulation; and (5) systems-level approaches to map signaling-gene regulation networks across the genome and transcriptome, with applications to cancer, metabolism, development, and a variety of human diseases. Expertise in next-generation sequencing approaches (e.g., RNA-seq, ChIP-seq), genome editing, or computational genomics is highly desirable.