Director / Sr. Director, Nonclinical Toxicology & PK Pinetree Therapeutics IncDirector / Sr. Director, Nonclinical Toxicology & PKCAToxicology Study Leadership: Design, oversee, and interpret non-GLP and GLP toxicology programs, including dose-range finding (DRF) studies, repeat-dose toxicity, and safety pharmacology in relevant species. You will be responsible for designing and overseeing preclinical and GLP toxicology studies, assessing tissue cross-reactivity, and managing PK assessments (both hands-on and via CROs) to support First-in-Human (FIH) dose estimations.
Sr. Scientific Director, Toxicology Neurocrine Biosciences Inc.Sr. Scientific Director, ToxicologySan Diego, CA$226,600–$309,000 / yearThe company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis and uterine fibroids , as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. Oversees the safety pharmacology and toxicology studies including protocol design, advises and directs the execution, data interpretation, and review of reports for new therapeutic entities of various modalities (small molecules, large molecules, peptide conjugates, oligonucleotides, and gene therapies).
Associate Director, Toxicology Denali TherapeuticsAssociate Director, ToxicologySouth San Francisco, CA$171,000–$223,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.
Associate Director, Toxicology Denali Therapeutics IncAssociate Director, ToxicologySouth San Francisco, CA$171,000–$223,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.
Associate Director, Toxicology Ionis Pharmaceuticals IncAssociate Director, ToxicologyCarlsbad, CA$172,501–$255,000 / yearWith multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. RESPONSIBILITIES: Serve as the nonclinical safety representative on cross-functional project teams, providing strategic toxicology input to support candidate selection, risk assessment, and program advancement.
SENIOR DIRECTOR, TOXICOLOGY Scripps ResearchSENIOR DIRECTOR, TOXICOLOGYSan Diego, CA$230,000–$280,000 / yearPart timeLeveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while reinvesting in further innovative research. Calibr-Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected tropical diseases, as well as age-related and degenerative diseases.
Director, Toxicology Vir Biotechnology, Inc.Director, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN dual-masked T-cell engagers across validated targets in solid tumor indications.
Director, Toxicology EvommuneDirector, ToxicologyPalo Alto, CaliforniaThe Director will serve as the toxicology representative on cross-functional program teams and will be responsible for the design, oversight, interpretation, and reporting of nonclinical safety studies supporting candidate selection, regulatory submissions, and clinical development. Support the preparation of nonclinical sections of regulatory submissions, including pre-IND briefing packages, INDs, clinical trial applications, investigator brochures, and responses to health authority questions.
Scientist I, Investigative Toxicology SGA Inc.Scientist I, Investigative ToxicologySouth San Francisco, CAThis individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies. Will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by: Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry.
Executive Director, Toxicology Eli Lilly and CoExecutive Director, ToxicologyCA$153,000–$290,400 / yearOur current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL). Serve as the primary nonclinical representative on Program Development Teams (PDTs) and at internal governance and external forums, effectively championing program strategy, presenting to regulatory authorities, and holding scientific ground with senior leadership, partners, CROs, and health authorities.
Senior Scientist, Toxicology Airna Corp incSenior Scientist, ToxicologySan Diego, CAAIRNA has raised $245 million in financing from a world-class syndicate of investors including Arch Venture Partners, Forbion, Venrock Healthcare Capital Partners, RTW Investments, Nextech Invest, and ND Capital. JOB DESCRIPTION: AIRNA is seeking a highly motivated Senior Scientist in Toxicology to help drive the pre-clinical safety strategy for the successful development of oligonucleotide programs across all stages of development.
Toxicology Research Scientist Vertex PharmaceuticalsToxicology Research ScientistSan Diego, CaliforniaThe successful candidate will have a proven track record of working with complex in vitro models, including primary cells and immune cells in 3D formats or co-culture systems, and will bring expertise in developing and applying innovative approaches to assess molecular toxicities. This lab-based role offers an exciting opportunity to lead the development of advanced 3D organoid models, organ-on-a-chip technologies, and fit-for-purpose assays to investigate toxicological mechanisms and support our therapeutic discovery and development efforts.
Senior Director, Toxicology Revolution MedicinesSenior Director, ToxicologyRedwood City, CaliforniaWe are seeking an experienced senior toxicologist, who combines scientific excellence with strategic leadership, for our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department, to work in close collaboration with Research and Development colleagues on new and ongoing portfolio projects. Collaborate with investigative toxicology team to drive mechanistic studies for target-, pathway- or off-target toxicities using in vitro and in vivo studies, including emerging new approach methodologies (NAMS) such as cell- and organoid-based assays and advanced imaging analyses.
Senior Director, Toxicology Revolution Medicines IncSenior Director, ToxicologyRedwood City, CA$244,000–$305,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. The Opportunity: We are seeking an experienced senior toxicologist, who combines scientific excellence with strategic leadership, for our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department, to work in close collaboration with Research and Development colleagues on new and ongoing portfolio projects.
Director, Toxicology Vir BiotechnologyDirector, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN ® dual-masked T-cell engagers across validated targets in solid tumor indications.
Director, Toxicology Vir Biotechnology IncDirector, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN dual-masked T-cell engagers across validated targets in solid tumor indications.
NewAssistant Director/Associate Director, Toxicology Ionis Pharmaceuticals Inc.Assistant Director/Associate Director, ToxicologyCarlsbad, CA$142,551–$255,000 / yearWith multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. SUMMARY: Ionis is seeking a talented and highly motivated Toxicologist to join the Preclinical Development Department and provide scientific leadership in the nonclinical safety assessment of drug candidates.
Senior Director, Toxicology Revolution Medicines, Inc.Senior Director, ToxicologyRedwood City, CA$244,000–$305,000 / yearThe Opportunity: We are seeking an experienced senior toxicologist, who combines scientific excellence with strategic leadership, for our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department, to work in close collaboration with Research and Development colleagues on new and ongoing portfolio projects. Collaborate with investigative toxicology team to drive mechanistic studies for target-, pathway- or off-target toxicities using in vitro and in vivo studies, including emerging new approach methodologies (NAMS) such as cell- and organoid-based assays and advanced imaging analyses.
Associate Director /Director- Scientific Operations, Specialty Toxicology RPM ReSearchAssociate Director /Director- Scientific Operations, Specialty ToxicologySan Diego, CaliforniaProvide a senior-level review of reports, protocols, and related documents for appropriate scientific content and interpretation of studies in collaboration with other senior staff. Primary responsibilities : Direct the science and operations involved in the direction, conduct, and execution of Preclinical Analytical Laboratory Sciences operations and studies.
Associate Director, Toxicology Protagonist Therapeutics IncAssociate Director, ToxicologyNewark, CA$185,000–$205,000 / yearThe Company also has a number of preclinical stage drug discovery programs addressing clinically and commercially validated targets including an oral IL-17 peptide antagonist, obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin programs. The base pay range for this position at commencement of employment is expected to be between $185K and $205K / year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.