Associate Director, Toxicology Denali TherapeuticsAssociate Director, ToxicologySouth San Francisco, CA$171,000–$223,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.
Associate Director, Toxicology Denali Therapeutics IncAssociate Director, ToxicologySouth San Francisco, CA$171,000–$223,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.
Director, Toxicology EvommuneDirector, ToxicologyPalo Alto, CaliforniaThe Director will serve as the toxicology representative on cross-functional program teams and will be responsible for the design, oversight, interpretation, and reporting of nonclinical safety studies supporting candidate selection, regulatory submissions, and clinical development. Support the preparation of nonclinical sections of regulatory submissions, including pre-IND briefing packages, INDs, clinical trial applications, investigator brochures, and responses to health authority questions.
Scientist I, Investigative Toxicology SGA Inc.Scientist I, Investigative ToxicologySouth San Francisco, CAThis individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies. Will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by: Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry.
Director, Toxicology Vir Biotechnology, Inc.Director, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN dual-masked T-cell engagers across validated targets in solid tumor indications.
Senior Director, Toxicology Revolution MedicinesSenior Director, ToxicologyRedwood City, CaliforniaWe are seeking an experienced senior toxicologist, who combines scientific excellence with strategic leadership, for our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department, to work in close collaboration with Research and Development colleagues on new and ongoing portfolio projects. Collaborate with investigative toxicology team to drive mechanistic studies for target-, pathway- or off-target toxicities using in vitro and in vivo studies, including emerging new approach methodologies (NAMS) such as cell- and organoid-based assays and advanced imaging analyses.
Senior Director, Toxicology Revolution Medicines IncSenior Director, ToxicologyRedwood City, CA$244,000–$305,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. The Opportunity: We are seeking an experienced senior toxicologist, who combines scientific excellence with strategic leadership, for our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department, to work in close collaboration with Research and Development colleagues on new and ongoing portfolio projects.
Director, Toxicology Vir Biotechnology IncDirector, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN dual-masked T-cell engagers across validated targets in solid tumor indications.
Director, Toxicology Vir BiotechnologyDirector, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN ® dual-masked T-cell engagers across validated targets in solid tumor indications.
Associate Director, Toxicology Protagonist Therapeutics IncAssociate Director, ToxicologyNewark, CA$185,000–$205,000 / yearThe Company also has a number of preclinical stage drug discovery programs addressing clinically and commercially validated targets including an oral IL-17 peptide antagonist, obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin programs. The base pay range for this position at commencement of employment is expected to be between $185K and $205K / year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
Senior Director, Disease Biology Arc InstituteSenior Director, Disease BiologyPalo Alto, CA$263,500–$325,500 / yearAlongside that build, this leader will direct Arc's existing in vivo and advanced cellular model teams to identify and validate novel targets, partnering with Arc's computational technology center to apply causal modeling and assemble a prioritized portfolio. Partner with computational biology and machine learning teams to surface new pathway insight, apply causal modeling to test target hypotheses, and draw on patient genetics and sample databases to validate and prioritize candidates.
Computational Scientist (Biology) AxiomComputational Scientist (Biology)San Francisco, CaliforniaThis creates a compounding loop: deeper customer understanding shapes the data we generate; better data improves frontier models, Axiom’s fine-tuned models, and our agentic infrastructure; stronger models and tooling expand the capabilities we can offer; and those capabilities are forward deployed into pharma's drug discovery workflows, where scientists use them to solve the highest value drug discovery problems. Analyze high-content imaging and transcriptomic data from primary human hepatocytes and multicellular hepatic systems, including phenotypes related to mitochondrial dysfunction, cholestasis, lipid accumulation, lysosomal stress, ER stress, cytotoxicity, and cellular morphology.
Director/Senior Director, Clinical Operations 5AM VenturesDirector/Senior Director, Clinical OperationsBerkeley, CA$210,000–$275,000 / yearHow should global clinical execution be designed and operationally managed for rare kidney diseases and genetically defined patient populations, including oversight of CROs, sites, and regional partners?. Which investigator networks, patient advocacy organizations, and clinical sites will be most critical to successful development, and how should those relationships be cultivated, coordinated, and leveraged throughout the clinical lifecycle?.
Sr Scientist/Principal Scientist, Discovery Oncology (In Vivo Biology) Eli Lilly and CompanySr Scientist/Principal Scientist, Discovery Oncology (In Vivo Biology)San Francisco, CA$71,250–$187,000 / yearWorking with a high degree of independence under the guidance of a senior scientific lead and/or director, the successful candidate will design, execute, and interpret in vivo (mouse and rat) studies - alongside supporting ex vivo and in vitro assays - to identify and validate novel druggable oncology targets, de-risk on-target toxicity liabilities, and advance targets from the pre-portfolio pipeline into the formal discovery portfolio. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Sr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology) Eli Lilly and CompanySr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology)San Francisco, California$71,250–$187,000 / yearWorking with a high degree of independence under the guidance of a senior scientific lead and/or director, the successful candidate will design, execute, and interpret in vivo (mouse and rat) studies — alongside supporting ex vivo and in vitro assays — to identify and validate novel druggable oncology targets, de-risk on-target toxicity liabilities, and advance targets from the pre-portfolio pipeline into the formal discovery portfolio. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Scientist LancesoftScientistSouth San Francisco, CA$49Skills: Candidate will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by: Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. This individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies.
Executive Director / Vice President, Biology & Translational Pharmacology Profluent IncExecutive Director / Vice President, Biology & Translational PharmacologyEmeryville, CA$270,000–$340,000 / yearProvide accountable leadership for cross-functional therapeutic program teams, integrating translational biology, genome editing, protein engineering, delivery, pharmacology, bioanalytics, CMC, regulatory, and preclinical development expertise. Outstanding written and verbal communication skills, with the ability to tailor scientific and strategic messages for audiences ranging from technical project teams to senior executives, board members, external advisors, partners, and generalist investors.
Executive Director / Vice President, Biology & Translational Pharmacology ProfluentExecutive Director / Vice President, Biology & Translational PharmacologyEmeryville, CAProvide accountable leadership for cross-functional therapeutic program teams, integrating translational biology, genome editing, protein engineering, delivery, pharmacology, bioanalytics, CMC, regulatory, and preclinical development expertise. Outstanding written and verbal communication skills, with the ability to tailor scientific and strategic messages for audiences ranging from technical project teams to senior executives, board members, external advisors, partners, and generalist investors.
Research Associate, Translational Biology (CONTRACT) SepternaResearch Associate, Translational Biology (CONTRACT)South San Francisco, CA$30–$40 / hourThe Veterinary Technician / Research Associate will initially be responsible for conducting in vivo rodent studies, with the potential to engage in additional ex vivo or in vitro studies in the Translational Sciences Department to support the advancement of Septerna's small molecule drug discovery pipeline. Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company.
Scientist (Lung Biology/Lung Organoids) Dawar ConsultingScientist (Lung Biology/Lung Organoids)South San Francisco, CaliforniaSeeking a highly motivated Scientist to develop, characterize, and qualify advanced human lung complex in vitro models to support drug discovery, disease modeling, and translational safety assessment. This fully onsite role will work with innovative systems including lung organoids, air-liquid interface (ALI) cultures, co-culture models, and lung-on-a-chip/microphysiological platforms .