Associate Director, Toxicology Denali Therapeutics IncAssociate Director, ToxicologySouth San Francisco, CA$171,000–$223,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.
Associate Director Toxicology Acadia Pharmaceuticals IncAssociate Director ToxicologySan Francisco, CA$155,000–$193,200 / yearKnowledge in the tools and procedures of preclinical safety assessment/toxicology experimentation, including the various experimental designs, statistical tools of data analyses, software applications available for data manipulation and presentation, and instrumentation pertinent to the research and ability to evaluate the advantages and disadvantages of each, in terms of applicability to the research at hand. We are developing the next wave of therapeutic advancements with a robust and diverse pipeline that includes mid- to late-stage programs in Alzheimer's disease psychosis and Lewy body dementia psychosis, along with earlier-stage programs that address other underserved patient needs.
Director, Toxicology EvommuneDirector, ToxicologyPalo Alto, CaliforniaThe Director will serve as the toxicology representative on cross-functional program teams and will be responsible for the design, oversight, interpretation, and reporting of nonclinical safety studies supporting candidate selection, regulatory submissions, and clinical development. Support the preparation of nonclinical sections of regulatory submissions, including pre-IND briefing packages, INDs, clinical trial applications, investigator brochures, and responses to health authority questions.
Scientist I, Investigative Toxicology SGA Inc.Scientist I, Investigative ToxicologySouth San Francisco, CAThis individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies. Will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by: Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry.
Director, Toxicology Pliant Therapeutics IncDirector, ToxicologySouth San Francisco, CA$232,000–$256,000 / yearThis role provides strong scientific and intellectual leadership across cross-functional teams, partners closely with internal stakeholders and external vendors, and represents nonclinical safety in interactions with global regulatory authorities. Make an Impact: Demonstrates strong ownership of nonclinical safety strategy and execution, driving programs forward with urgency while ensuring high-quality, regulatory-ready results that directly influence pipeline advancement.
NewDirector, Toxicology Vir BiotechnologyDirector, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN ® dual-masked T-cell engagers across validated targets in solid tumor indications.
NewDirector, Toxicology Vir Biotechnology IncDirector, ToxicologySan Francisco, CA$203,500–$284,000 / yearIn this role, you will provide scientific leadership for toxicology and safety assessment activities from candidate selection through clinical development, working closely with cross-functional teams and external partners to advance programs efficiently and effectively. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN dual-masked T-cell engagers across validated targets in solid tumor indications.
Director/Senior Director, Toxicology Lakefront Biotherapeutics NVDirector/Senior Director, ToxicologySan Francisco, CA$230,000–$300,000 / yearLakefront Biotherapeutics is a global biotech with offices in Belgium, Chicago and San Francisco, focused on building a differentiated immunology and inflammation pipeline to address serious diseases with high unmet medical need. Design, oversee, and interpret GLP and non-GLP toxicology studies including single- and repeat-dose tox, genotoxicity, reproductive and developmental toxicology, carcinogenicity, and safety pharmacology.
Toxicology Management Specialist (Madera, CA) UCSF Medical CenterToxicology Management Specialist (Madera, CA)San Francisco, CAPost graduate or clinical pharmacy residency or fellowship trainingAAPCC Certification as a Specialist in Poison Information or as a Diplomate of the American Board of Applied ToxicologyInvolvement in scholarly activitiesMultilingualPrior emergency medicine or critical care clinical pharmacy experienceExperience with study design, study data analysis, and manuscript preparationFormal teaching experience of clinical learners. Minimum of 2 years of experience in clinically-oriented pharmacy practice OR 2 years prior Poison Control Center experience or an equivalent combination of education and experience; and knowledge and ability necessary for the successful performance of the duties assigned to the position.
Associate Director, Toxicology Protagonist Therapeutics IncAssociate Director, ToxicologyNewark, CA$185,000–$205,000 / yearThe Company also has a number of preclinical stage drug discovery programs addressing clinically and commercially validated targets including an oral IL-17 peptide antagonist, obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin programs. The base pay range for this position at commencement of employment is expected to be between $185K and $205K / year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
Senior Scientist II Occupational & Environmental Toxicologist AbbVie IncSenior Scientist II Occupational & Environmental ToxicologistSouth San Francisco, CAScientist II Qualifications: Bachelor's Degree in toxicology or related discipline and typically 12 years of experience OR Master's Degree in toxicology or related discipline and typically 10 years of experience OR PhD in toxicology or related discipline and typically 4 years of experience. This includes toxicology support for extractables and leachables, health-based exposure limits (HBELs) including permitted daily exposure limits (PDEs) and occupational exposure limits (OELs), environmental risk assessments (ERA), and other contaminants.
Hazardous Materials Specialist I/II/III (Open & Promotional) County of San MateoHazardous Materials Specialist I/II/III (Open & Promotional)San Mateo, CA$7,959.47–$12,367.33 / yearCurrent County of San Mateo and County of San Mateo Superior Court of California employees with at least six months (1040 hours) of continuous service in a classified regular, probationary, Confidential and Management extra-help/limited term, and SEIU or AFSCME represented extra help/limited term positions prior to the final filing date will receive five points added to their final passing score on this examination. Hazardous Materials Specialists (HMS) perform inspections, enforcement activities and special assignments to ensure regulatory compliance at underground storage tank facilities, hazardous waste generators, tiered permitting facilities, hazardous materials handlers and above ground tank sites.
Senior Specialist, Data Science Merck & Co IncSenior Specialist, Data ScienceSan Francisco, CA$129,000–$203,100 / yearThe successful candidate will lead cross-functional projects, deliver production-grade models and agentic systems, and help establish governance and MLOps practices that ensure reproducibility, transparency, and ethical AI use in preclinical research. Hands-on experience with large language models and agentic AI frameworks (fine-tuning, prompt engineering, multi-agent orchestration, tool use, and API-based production orchestration) required.
Computational Scientist (Biology) AxiomComputational Scientist (Biology)San Francisco, CaliforniaThis creates a compounding loop: deeper customer understanding shapes the data we generate; better data improves frontier models, Axiom’s fine-tuned models, and our agentic infrastructure; stronger models and tooling expand the capabilities we can offer; and those capabilities are forward deployed into pharma's drug discovery workflows, where scientists use them to solve the highest value drug discovery problems. Analyze high-content imaging and transcriptomic data from primary human hepatocytes and multicellular hepatic systems, including phenotypes related to mitochondrial dysfunction, cholestasis, lipid accumulation, lysosomal stress, ER stress, cytotoxicity, and cellular morphology.
Scientist LancesoftScientistSouth San Francisco, CA$49Skills: Candidate will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by: Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. This individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies.
Executive Director / Vice President, Biology & Translational Pharmacology Profluent IncExecutive Director / Vice President, Biology & Translational PharmacologyEmeryville, CA$270,000–$340,000 / yearProvide accountable leadership for cross-functional therapeutic program teams, integrating translational biology, genome editing, protein engineering, delivery, pharmacology, bioanalytics, CMC, regulatory, and preclinical development expertise. Outstanding written and verbal communication skills, with the ability to tailor scientific and strategic messages for audiences ranging from technical project teams to senior executives, board members, external advisors, partners, and generalist investors.
NewScientist (Lung Biology/Lung Organoids) Dawar Consulting, Inc.Scientist (Lung Biology/Lung Organoids)South San Francisco, CASeeking a highly motivated Scientist to develop, characterize, and qualify advanced human lung complex in vitro models to support drug discovery, disease modeling, and translational safety assessment. This fully onsite role will work with innovative systems including lung organoids, air-liquid interface (ALI) cultures, co-culture models, and lung-on-a-chip/microphysiological platforms .
NewResearch Associate, Translational Biology (CONTRACT) SepternaResearch Associate, Translational Biology (CONTRACT)South San Francisco, CA$30–$40 / hourThe Veterinary Technician / Research Associate will initially be responsible for conducting in vivo rodent studies, with the potential to engage in additional ex vivo or in vitro studies in the Translational Sciences Department to support the advancement of Septerna's small molecule drug discovery pipeline. Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company.
Computational Scientist (Medicinal Chemistry) AxiomComputational Scientist (Medicinal Chemistry)San Francisco, CaliforniaThis creates a compounding loop: deeper customer understanding shapes the data we generate; better data improves frontier models, Axiom’s fine-tuned models, and our agentic infrastructure; stronger models and tooling expand the capabilities we can offer; and those capabilities are forward deployed into pharma's drug discovery workflows, where scientists use them to solve the highest value drug discovery problems. Influence active drug programs by helping teams understand whether toxicity risk is driven by exposure, potency, off-target biology, reactive metabolites, transporters, mitochondrial liability, cholestasis, immune mechanisms, or other drivers.
Senior Dir, In-Vivo & Non-Clinical Pharmacology Bristol-Myers Squibb CoSenior Dir, In-Vivo & Non-Clinical PharmacologyCA$252,640–$306,137 / yearThis leader will partner deeply with Research leadership and the Pharmacology, DMPK, Toxicology, and Translational Science units to deliver the applications, workflow capabilities, AI, and supporting data flows that enable non-clinical decisions across in-vivo biology, DMPK, ADME, non-clinical safety, toxicology, and bioanalytical science. Non-clinical pharmacology generates the evidence that determines which candidates enter humans, and this role matters now because scientists need better integrated applications, AI, and workflows to generate, interpret, and act on that evidence with greater speed and confidence.
NewDirector Business Development-West Coast Frontage Clinical Services IncDirector Business Development-West CoastHayward, CA$120,000–$160,000 / yearOur core competencies include pre-clinical, drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials. The focus of the role is new business development for pre-clinical / non-clinical toxicology and drug safety services in pharmaceutical drug development, and services including DMPK and related bioanalytical.
Principal/Sr. Principal Scientist - Development Genentech IncPrincipal/Sr. Principal Scientist - DevelopmentSouth San Francisco, CA$141,500–$262,900 / yearThe successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech's oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics. Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
NewPharmacist SR EX UCSF Medical CenterPharmacist SR EXSan Francisco, CAMinimum of 2 years of experience in clinically-oriented pharmacy practice OR 2 years prior Poison Control Center experience or an equivalent combination of education and experience; and knowledge and ability necessary for the successful performance of the duties assigned to the position. The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
Principal Environmental Risk Assessor Geosyntec Consultants, Inc.Principal Environmental Risk AssessorOakland, CaliforniaFull timeThis position is ideal for an accomplished leader in toxicology, ecological risk assessment (ERA), and human health risk assessment (HHRA) who can help grow and lead complex site investigation, remediation, and redevelopment projects across industrial, energy, and public-sector markets. The role emphasizes technical leadership on CERCLA, RCRA, PFAS, sediment, vapor intrusion, and risk-based cleanup projects; trusted advisory relationships with clients and regulators; and collaboration across multidisciplinary teams.