NewPrincipal Scientist, Therapeutic Discovery Capable LabsPrincipal Scientist, Therapeutic DiscoverySan Francisco, CaliforniaConvert research concepts into executable plans by identifying targets, mechanisms, modalities, assay strategies, biomarkers, and establishing clear progression criteria, budgets, and timelines. Execute all stages of the research lifecycle: hypothesis development, literature review, experimental design and execution, data analysis, and program evaluation, collaborating closely with scientific colleagues.
Principal Scientist, Process Chemistry California Life CompanyPrincipal Scientist, Process ChemistrySouth San Francisco, CA$197,000–$245,000 / yearCalico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Who We are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging.
Sr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology) Eli Lilly and CompanySr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology)San Francisco, CaliforniaWorking with a high degree of independence under the guidance of a senior scientific lead and/or director, the successful candidate will design, execute, and interpret in vivo (mouse and rat) studies — alongside supporting ex vivo and in vitro assays — to identify and validate novel druggable oncology targets, de-risk on-target toxicity liabilities, and advance targets from the pre-portfolio pipeline into the formal discovery portfolio. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Sr Scientist/Principal Scientist, Discovery Oncology (In Vivo Biology) Eli Lilly and CompanySr Scientist/Principal Scientist, Discovery Oncology (In Vivo Biology)San Francisco, CA$71,250–$187,000 / yearWorking with a high degree of independence under the guidance of a senior scientific lead and/or director, the successful candidate will design, execute, and interpret in vivo (mouse and rat) studies - alongside supporting ex vivo and in vitro assays - to identify and validate novel druggable oncology targets, de-risk on-target toxicity liabilities, and advance targets from the pre-portfolio pipeline into the formal discovery portfolio. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Principal Scientist (Cell Line Development) Exelixis Inc.Principal Scientist (Cell Line Development)Alameda, CA$150,000–$213,000 / yearEDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS: Education: Bachelor's degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of eleven (11) years of experience in the biotechnology/pharmaceutical industry; or, Master's degree in related scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of nine (9) years of experience in the biotechnology/pharmaceutical industry. SUMMARY/JOB PURPOSE: As a member of the Biotherapeutics group, the incumbent will play a key role in supporting the group's discovery and preclinical development efforts by possessing skills and experience in recombinant antibody and bispecific antibody production and purification/characterization.
Principal Scientist, Process Sciences Allogene TherapeuticsPrincipal Scientist, Process SciencesSouth San Francisco, CA$155,000–$180,000 / yearLed by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease.
Principal Scientist - Underwater Acoustics Sofar OceanPrincipal Scientist - Underwater AcousticsSan Francisco, CARemote$137,000–$185,000 / yearAdvance methods for mapping and characterizing the ocean soundscape-including ambient noise fields, acoustic propagation conditions (e.g., sound-speed structure and transmission loss), and the oceanographic and geoacoustic context that drives them. Design and conduct field experiments, at-sea data collection, data analyses, and modeling and simulation studies (including propagation and detection-performance modeling) to evaluate acoustic system performance under realistic ocean conditions.
Principal Scientist, Commercial And Late-Stage Purification Process Development Denali TherapeuticsPrincipal Scientist, Commercial And Late-Stage Purification Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearSupport lifecycle management activities for commercial products, including process improvements, tech transfer validation activities, local and cross-site change management, regulatory filing updates (CBE, PAS, Ex-US expansion), and responses to health authority questions. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
Principal Scientist, Commercial & Late-Stage Cell Culture Process Development Denali TherapeuticsPrincipal Scientist, Commercial & Late-Stage Cell Culture Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearSupport lifecycle management activities for commercial products, including process improvements, tech transfer validation activities, local and cross-site change management, regulatory filing updates (CBE, PAS, Ex-US expansion), and responses to health authority questions. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
Principal Scientist, Computational Chemistry Cytokinetics, IncorporatedPrincipal Scientist, Computational ChemistrySouth San Francisco, CA$202,500–$236,250 / yearLeveraging state-of-the-art machine learning technologies such as QSAR modeling, de novo design tools, and reaction prediction algorithms, you will develop robust workflows and processes that enhance compound design capabilities and enable data-driven decision-making. Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.
Principal Scientist, Purification Process Development Denali TherapeuticsPrincipal Scientist, Purification Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Qualifications/Skills: Typically requires a PhD in Biology, Biochemistry, Chemical Engineering or related scientific discipline, plus 10+ years' of related work experience.
Principal Scientist / Associate Director, Agentic AI Research for Materials Science Lila SciencesPrincipal Scientist / Associate Director, Agentic AI Research for Materials ScienceSan Francisco, MassachusettsFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Environmental Scientist (Natural Resources) Project Resource CollectivePrincipal Environmental Scientist (Natural Resources)Oakland, CaliforniaCollaborating with internal subject matter experts (biologists, archaeologists, GIS specialists, planners, regulatory specialists, and engineers) and external technical partners, protection agencies, and state or federal lead agencies. Experience leading projects/programs and working in dynamic, collaborative environments that require flexibility in assuming new roles and changing project directions.
Principal Scientist, Inflammation Amgen Inc.Principal Scientist, InflammationSouth San Francisco, CAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Familiarity with small and large molecule drug discovery, mechanism of action studies, ELISA, MSD, and flow cytometry-based immune cell profiling, single-cell RNA sequencing (scRNA-Seq), CRISPR/Cas9, and omics data analysis experience a plus.
Principal Scientist, Antibody Engineering & Rational Design California Life CompanyPrincipal Scientist, Antibody Engineering & Rational DesignSouth San Francisco, CA$198,000–$241,000 / yearCalico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Demonstrated ability to work intimately with data scientists and ML engineers and able to articulate biological constraints (e.g., immunogenicity, manufacturability) to computational teams and interpret their in silico outputs for experimental validation.
Principal Scientist, Bioinformatics Nkarta, Inc.Principal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Principal Scientist, Translational Genetics CytokineticsPrincipal Scientist, Translational GeneticsSouth San Francisco, California$202,500–$236,250 / yearCytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. Analyze and integrate multi-omics data (genomics, transcriptomics, proteomics, metabolomics) to identify causal variants and pathways associated with cardiovascular diseases.
Principal Scientist, CMC Analytical Development - Commercial Products Denali TherapeuticsPrincipal Scientist, CMC Analytical Development - Commercial ProductsSouth San Francisco, CA$159,000–$207,000 / yearAs the product transitions into routine commercial production and Denali pursues marketing applications in additional countries, we are seeking a Principal Scientist to join our Large Molecule Analytical Development Team to serve as a Commercial Analytical Lifecycle Lead. The Commercial Analytical Lifecycle Lead is expected to partner closely with peer Late Stage Analytical Development and Bioassay Development Leads responsible for driving successful analytical transfer & registration of a second-source manufacturing and QC site.
Senior Principal Scientist (Antibody Drug Conjugate) Exelixis Inc.Senior Principal Scientist (Antibody Drug Conjugate)Alameda, CA$169,500–$239,500 / yearEDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS: Education: BS/BA degree in Chemistry, Biochemistry, Chemical Biology or related discipline and a minimum of 13 years of related experience; or, MS/MA degree in Chemistry, Biochemistry, Chemical Biology or related discipline and a minimum of 11 years of related experience; or, PhD in Chemistry, Biochemistry, Chemical Biology or related discipline and a minimum of 8 years of related experience; or, Equivalent combination of education and experience. Apply and advance both stochastic (interchain cysteine) and site-specific conjugation platforms (engineered cysteine, transglutaminase, sortase, glycan remodeling, unnatural amino acids, native disulfide re-bridging); contribute to the evaluation and adoption of new platforms.
Principal Scientist, Analytical Development Sana BiotechnologyPrincipal Scientist, Analytical DevelopmentSouth San Francisco, CA$200,000–$240,000 / yearPhysical Demands: Employees in this position may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements. Act as a key contributor in developing and qualifying pivotal stage potency, immunoassay, and other cell-based methods to support the characterization, process development, release testing, and stability testing of cell therapy products.