Principal Scientist, Translational Oncology - Single Cell and Spatial Genomics, Solid Tumors Natera IncPrincipal Scientist, Translational Oncology - Single Cell and Spatial Genomics, Solid TumorsCA$171,900–$214,950 / yearThe Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location.
Principal Scientist (Antibody Engineering) Grifols SAPrincipal Scientist (Antibody Engineering)San Carlos, CA$165,000–$205,000 / yearPrimary responsibilities for role: Independently design and manage experiments for testing next-generation antibody therapeutics, including construct design, expression and purification strategies, and implementation of novel analytical assays. Our core technology utilizes a microfluidic droplet system to capture and immortalize diverse immune repertoires, which can then be mined for exceptional monoclonals or enriched and used as high-potency polyclonal therapeutics.
Senior / Principal Scientist Lung Modeling, Complex in vitro Systems (CiS) Laboratory Genentech IncSenior / Principal Scientist Lung Modeling, Complex in vitro Systems (CiS) LaboratorySouth San Francisco, CA$120,700–$224,100 / yearThe Opportunity: As an integral member of our dynamic team, you will: Develop, design, execute, and characterize advanced lung in vitro models at the bench, including airway and alveolar organoids, air-liquid interface (ALI) 3D cultures, organ-on- chip, and other microphysiological systems (MPS) to address critical questions in lung drug discovery and development. While primarily a senior laboratory-based role driving scientific innovation at the bench, this candidate will also provide technical mentorship to junior scientists, collaborate closely with internal cross-functional project teams, and participate in external collaborations.
Principal Scientist, Global Patient Safety Surveillance Revolution MedicinesPrincipal Scientist, Global Patient Safety SurveillanceRedwood City, CaliforniaServe as the lead principal subject matter expert for the design, development, maintenance, and support of one or more core GPS processes (i.e. comparative benefit-risk, signal detection & management, risk management, aggregate reporting, etc.) in compliance with applicable Good Clinical Practice (GCP), Good Pharmacovigilance Practice (GVP), Good Documentation Practices (GDocP), etc., in alignment with the company’s mission and objectives. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Scientist, Global Patient Safety Surveillance Revolution Medicines IncPrincipal Scientist, Global Patient Safety SurveillanceRedwood City, CA$211,000–$264,000 / yearResponsibilities include: Serve as the lead principal subject matter expert for the design, development, maintenance, and support of one or more core GPS processes (i.e. comparative benefit-risk, signal detection & management, risk management, aggregate reporting, etc.) in compliance with applicable Good Clinical Practice (GCP), Good Pharmacovigilance Practice (GVP), Good Documentation Practices (GDocP), etc., in alignment with the company's mission and objectives. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Scientist, Downstream Process Development (Contract) - AW Adverum Biotechnologies IncPrincipal Scientist, Downstream Process Development (Contract) - AWRedwood City, CA$80–$90 / hourThe successful candidate will participate in late-stage activities including design and optimization of the process as needed using historical batch data and manufacturing needs; process characterization; and tech-transfer of downstream processes to support clinical and commercial manufacturing. Leveraging the research capabilities of its proprietary intravitreal (IVT) platform, Adverum is developing durable, single-administration therapies designed to be delivered in physicians' offices to eliminate the need for frequent ocular injections to treat these diseases.
Principal Scientist I, Molecular Lab Research and Early Development F. Hoffmann-La Roche LtdPrincipal Scientist I, Molecular Lab Research and Early DevelopmentPleasanton, CA$111,000–$206,500 / yearYou will prototype and optimize different sequencing assay workflows by aligning pharma project needs, designing and implementing rigorous experiments, and applying established and innovative procedures to enable end-to-end solutions; You will proactively highlight issues, troubleshoot assays, and resolve technical challenges by applying broad knowledge of molecular biology techniques and accumulated experience. The goal will be to build sequencing assays on our revolutionary Axelios Sequencing platform and translating the immense potential of our Sequencing by Expansion (SBX) technology into real-world assays that can benefit patients.
Principal Scientist I, Molecular Lab Research and Early Development RochePrincipal Scientist I, Molecular Lab Research and Early DevelopmentPleasanton, CaliforniaYou will prototype and optimize different sequencing assay workflows by aligning pharma project needs, designing and implementing rigorous experiments, and applying established and innovative procedures to enable end-to-end solutions; You will proactively highlight issues, troubleshoot assays, and resolve technical challenges by applying broad knowledge of molecular biology techniques and accumulated experience. The goal will be to build sequencing assays on our revolutionary Axelios Sequencing platform and translating the immense potential of our Sequencing by Expansion (SBX) technology into real-world assays that can benefit patients.
Principal Scientist, Clinical Research - Immunology/Dermatology Merck & Co IncPrincipal Scientist, Clinical Research - Immunology/DermatologySouth San Francisco, CA$255,800–$402,700 / yearAssist the Senior Director, Associate Vice-President/Vice-President and Product Development Team Lead in ensuring that appropriate corporate personnel is informed of the progress of studies of our company and competitors' drugs and internal and external expert opinion on scientific questions relevant to their areas of responsibility. With a focus on late-stage development, the Clinical Director will manage the entire cycle of clinical development, including determination of appropriate disease indications to pursue and subsequent study design, initiation, execution, monitoring, analysis, regulatory filing, and publication.
Principal Scientist, Drug Product Process Science Allogene Therapeutics IncPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
Principal Scientist, Drug Product Process Science Allogene TherapeuticsPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
Senior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery) Genentech IncSenior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery)South San Francisco, CA$147,800–$274,400 / yearIn this role, you will: As a Senior Scientist: • Develop novel machine learning methods to answer challenging research questions in large molecule drug discovery • Work with biological and chemical data from heterogeneous sources • Contribute to an initiative to consolidate projects in machine learning theory into a single coherent model for lab-in-the-loop drug discovery. As a Principal Scientist: • Develop novel machine learning methods to answer challenging research questions in large molecule drug discovery • Work with biological and chemical data from heterogeneous sources • Lead an initiative to consolidate projects in machine learning theory into a single coherent model for lab-in-the-loop drug discovery.
Supervising Principal Scientist, Process Development Cellares CorpSupervising Principal Scientist, Process DevelopmentSouth San Francisco, CA$90,000–$210,000 / yearThe primary focus of this position is to provide organizational leadership and technical insight into the onboarding and optimization of new cell therapy processes to expand and drive continuous improvement of the Cellares platform. Partnering with Cellares enables academics, biotechs, and pharma companies to accelerate drug development and scale out manufacturing, lower process failure rates, lower manufacturing costs, and meet global patient demand.
Principal Scientist, Immunology Jade BiosciencesPrincipal Scientist, ImmunologySan Francisco, CaliforniaRemote$175,000–$190,000 / yearThis role will provide scientific leadership across immunology-driven research activities that support Jade’s pipeline programs, including mechanism-of-action studies, disease biology assessment, indication evaluation, and translational strategy. Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs.
Principal Scientist, Computational Chemistry Eikon Therapeutics IncPrincipal Scientist, Computational ChemistryMillbrae, CA$204,000–$223,250 / yearDeliver virtual screening workflows that leverage physics- and AI-based modeling methods involving ligand- and structure-based methods, ensemble docking, molecular dynamics, and free energy calculations. We seek a Principal Scientist in Computational Chemistry with a demonstrated ability of successfully applying in silico technologies to drive the discovery of quality lead-like molecules against hard to drug therapeutic targets.
Principal Scientist, IVD Reagent Development and Manufacturing Delfi Diagnostics IncPrincipal Scientist, IVD Reagent Development and ManufacturingPalo Alto, CA$180,000–$230,000 / year2+ years of experience developing reagent specifications (format, fill volume tolerance, closure, label, shelf, and in-use stability), reagent integrations with automated platforms, and transferring reagent manufacturing from R&D to an internal department or an external contract reagent manufacturer. 3+ years of developing IVD diagnostic tests with NGS cfDNA/multi-omic assay technologies from plasma (e.g., DNA fragments, RNA, small variants, methylation, or immunoassays) under 21 CFR Part 820 or ISO 13485.
Principal/Sr. Principal Scientist - Development Genentech IncPrincipal/Sr. Principal Scientist - DevelopmentSouth San Francisco, CA$141,500–$262,900 / yearThe successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech's oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics. Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
Senior / Principal Scientist, AI for Protein Engineering Lila SciencesSenior / Principal Scientist, AI for Protein EngineeringSan Francisco, CaliforniaWithin Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila's biomolecule design programs from in silico hypothesis to wet-lab validated lead. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Principal Scientist - Translational Medicine (Tumor Microenvironment) Genentech IncPrincipal Scientist - Translational Medicine (Tumor Microenvironment)South San Francisco, CA$141,500–$262,900 / yearDesign and implement translational research plans leveraging clinical samples, multi-omic profiling, spatial biology, single-cell technologies, functional immune assays, and emerging AI-enabled analytical approaches, including agentic AI tools, to uncover mechanisms of response, resistance, tumor microenvironment interactions, and disease evolution. This role also includes developing and leading hypothesis-driven translational research focused on identifying and developing novel biomarkers of therapeutic response and resistance, as well as uncovering disease-specific mechanistic insights.
Senior / Principal Scientist, AI for Protein Engineering Lila Sciences IncSenior / Principal Scientist, AI for Protein EngineeringSan Francisco, CA$268,000–$358,000 / yearWithin Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila''s biomolecule design programs from in silico hypothesis to wet-lab validated lead. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Senior / Principal Scientist, Foundation Models for life Sciences Lila Sciences IncSenior / Principal Scientist, Foundation Models for life SciencesSan Francisco, CA$268,000–$384,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Scientist - Agentic Product ADOBE IncPrincipal Scientist - Agentic ProductCA$248,900–$360,500 / yearDeep, hands-on expertise with large language models - including practical fluency with LLM APIs, prompt engineering at scale, fine-tuning and RLHF concepts, context window management, retrieval-augmented generation, and the operational realities of running LLM-backed systems in production. Adobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity.
Principal Scientist, Bioinformatics Nkarta IncPrincipal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Principal Scientist, Generation Data Architect (Image & Video & Audio) ADOBE IncPrincipal Scientist, Generation Data Architect (Image & Video & Audio)San Jose, CA$268,000–$388,000 / yearAdobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity. Your work will directly impact how Firefly understands concepts like style, motion, and real-world variation-helping deliver more realistic, controllable, and useful creative tools to millions of users.
NewSenior Principal Scientist (Antibody Drug Conjugate) Exelixis IncSenior Principal Scientist (Antibody Drug Conjugate)Alameda, CA$169,500–$239,500 / yearEDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS: Education: BS/BA degree in Chemistry, Biochemistry, Chemical Biology or related discipline and a minimum of 13 years of related experience; or, MS/MA degree in Chemistry, Biochemistry, Chemical Biology or related discipline and a minimum of 11 years of related experience; or, PhD in Chemistry, Biochemistry, Chemical Biology or related discipline and a minimum of 8 years of related experience; or, Equivalent combination of education and experience. Apply and advance both stochastic (interchain cysteine) and site-specific conjugation platforms (engineered cysteine, transglutaminase, sortase, glycan remodeling, unnatural amino acids, native disulfide re-bridging); contribute to the evaluation and adoption of new platforms.
Principal Scientist, Translational Genetics Cytokinetics IncPrincipal Scientist, Translational GeneticsSouth San Francisco, CA$202,500–$236,250 / yearCytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. Analyze and integrate multi-omics data (genomics, transcriptomics, proteomics, metabolomics) to identify causal variants and pathways associated with cardiovascular diseases.
Principal Scientist, Bioinformatics Nkarta, Inc.Principal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Principal Scientist Recruiting From ScratchPrincipal ScientistSan Francisco, CaliforniaWe're representing a dynamic company in the consumer healthcare and life sciences sector that is focused on developing innovative solutions for cleaner and safer products. This organization is committed to advancing research and applied science, fostering a collaborative environment where creativity and scientific rigor thrive.
NewPrincipal Scientist, Synthetic Molecule Process Chemistry, Genentech Research Genentech IncPrincipal Scientist, Synthetic Molecule Process Chemistry, Genentech ResearchSouth San Francisco, CA$144,900–$269,100 / yearEventual route selection for late stage GMP API manufacturing is also the responsibility of the Scientist and includes the concepts of safe, efficient, robust, environmentally sound chemistry and extends to the synthesis of the regulatory starting materials and establishment of a robust supply chain. Strong working knowledge of the latest developments in contemporary synthetic organic and/or process chemistry including chemo- and bio-catalysis, organometallic chemistry as well as expertise in asymmetric transformations, heterocyclic chemistry, and/or peptide chemistry.
Principal Scientist, Analytical Development Sana Biotechnology IncPrincipal Scientist, Analytical DevelopmentSouth San Francisco, CA$200,000–$240,000 / yearPhysical Demands: Employees in this position may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements. Act as a key contributor in developing and qualifying pivotal stage potency, immunoassay, and other cell-based methods to support the characterization, process development, release testing, and stability testing of cell therapy products.
Principal Scientist, Biomarker Data Sciences Biogen IncPrincipal Scientist, Biomarker Data SciencesSan Francisco, CA$141,000–$188,000 / yearAbout This Role: As a Principal Scientist in Biomarker Data Sciences within the Clinical Biomarkers group at the West Coast Hub, you will lead the charge in multi-omics analyses of extensive clinical trial datasets, with a particular focus on NGS and proteomics. Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
Principal Scientist, Clinical Biomarkers Biogen IncPrincipal Scientist, Clinical BiomarkersSan Francisco, CA$140,000–$187,000 / yearRegular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. Positioned within the West Coast Hub (WCH) team, you will work closely with Discovery Biomarkers, Clinical Development, Clinical Pharmacology, Biostatistics, Regulatory, and external CROs to ensure the timely delivery of high-quality biomarker data.
Principal Scientist - PKDM (Large Molecule Project Team Representative) Amgen IncPrincipal Scientist - PKDM (Large Molecule Project Team Representative)South San Francisco, CAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. You will provide strategic and scientific leadership across multidisciplinary project teams while partnering closely with experts in pharmacology, toxicology, protein sciences, medicinal chemistry, pharmaceutical sciences, clinical pharmacology, and regulatory sciences.
Principal Scientist, Pathology Genentech IncPrincipal Scientist, PathologyCA$181,200–$336,400 / yearThe responsibilities of this Principal Scientist project pathologist position will include: Provide veterinary clinical, technical, and scientific expertise on in-house and CRO-based studies from protocol development through necropsy, clinical pathology, and histopathology evaluations, pathology peer review and final report generation. Working in a team environment, Translational Safety Project Pathologists participate in and may lead the strategic design, implementation, and data analysis of non-GLP investigative and GLP regulatory studies to ensure the comprehensive, highly integrated safety profiling of Genentech drug candidates.
Principal Scientist, Translational Genomics and Proteomics Center Genentech IncPrincipal Scientist, Translational Genomics and Proteomics CenterSouth San Francisco, CA$143,200–$266,000 / yearThe successful candidate will develop and apply genomic, proteomic, and reductionist approaches to uncover mechanisms of antigen processing and presentation in myeloid and lymphoid cells and the relevance of these pathways to infections, autoimmunity, and tumor immunity. The Translational Genomics and Proteomics Center at Genentech Research and Early Development integrates innovative genomic, proteomic, and computational approaches to advance our understanding of human biology and disease.
Principal Scientist - Cell Therapy Drug Product Process Development Genentech IncPrincipal Scientist - Cell Therapy Drug Product Process DevelopmentSouth San Francisco, CA$120,800–$224,300 / yearThis "Lead from the Bench" position requires effective participation in cross-functional teams with members from Genentech Research and Early Development (gRED), Cell Therapy Engineering and Process Development (CTED), Analytical Development and Quality Control (ADQC), Manufacturing Sciences and Technology (MSAT), Quality, and Regulatory departments. The selected candidate will work as a part of the Cell Therapy Drug Product Process Development Team that is responsible for optimizing the formulation and drug product processing unit operations and clinical administration procedures for allogeneic CAR T cells, retinal pigment epithelial cells, and other cell therapy modalities.
Principal Scientist, Peptide Therapeutics Genentech IncPrincipal Scientist, Peptide TherapeuticsSouth San Francisco, CA$143,200–$265,900 / yearSynthetic Mastery: Utilize expert-level skills in solid-phase peptide synthesis, solution-phase organic chemistry, and specialized macrocyclization or ligation strategies. In this lab-based leadership role, you will combine hands-on synthetic expertise with strategic oversight, driving the discovery and optimization of peptide therapeutics across the full development lifecycle.
Principal Scientist, Cancer Pharmacology, Translational Research Revolution Medicines IncPrincipal Scientist, Cancer Pharmacology, Translational ResearchRedwood City, CA$190,000–$238,000 / yearThe Opportunity: As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Scientist, Analytical Chemistry Revolution Medicines IncPrincipal Scientist, Analytical ChemistryRedwood City, CA$190,000–$238,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Design and implementation of discovery analytics, analytical data integration through collaboration with LabOS team, Data Sciences and Data Analytics functions to develop and implement automated high-throughput analytical methods that enhance efficiency and data quality.
Principal Scientist, Cancer Pharmacology, Translational Research Revolution MedicinesPrincipal Scientist, Cancer Pharmacology, Translational ResearchRedwood City, CaliforniaAs a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Scientist, Bioanalytic Epicrispr Biotechnologies IncPrincipal Scientist, BioanalyticSouth San Francisco, CA$165,000–$184,000 / yearOpportunity: Epicrispr Biotechnologies is seeking a highly motivated and experienced Principal Scientist, Bioanalytical to lead the development and execution of bioanalytical strategies supporting our pipeline. Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.
Senior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug Discovery Genentech IncSenior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug DiscoverySouth San Francisco, CA$167,400–$310,800 / yearThe new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide. Research-to-Production Impact: Partner with researchers and cross-functional teams to move models from research prototypes to production-ready systems that support active discovery programs.
Senior Principal Scientist, Cardiovascular, Translational Development Bristol-Myers Squibb CoSenior Principal Scientist, Cardiovascular, Translational DevelopmentBrisbane, CAKeeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology Keeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology. • Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays.
NewPrincipal Scientist / Associate Director, Agentic AI Research for Materials Science Lila SciencesPrincipal Scientist / Associate Director, Agentic AI Research for Materials ScienceSan Francisco, MassachusettsFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Senior Scientist / Principal Scientist, Complex in Vitro Systems Genentech IncSenior Scientist / Principal Scientist, Complex in Vitro SystemsSouth San Francisco, CA$120,700–$224,100 / yearResponsibilities include culturing and characterizing state-of-the-art ocular CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets; and maintaining rigorous, high-quality documentation. The Position: The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Senior Scientist / Principal Scientist to develop, characterize, and qualify advanced complex in vitro models to support Genentech's mission of delivering safe and efficacious medicines.
NewPrincipal Scientist / Associate Director, Agentic AI Research for Materials Science Lila Sciences IncPrincipal Scientist / Associate Director, Agentic AI Research for Materials ScienceSan Francisco, CA$288,000–$420,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Scientist, Computational Chemistry Cytokinetics IncPrincipal Scientist, Computational ChemistrySouth San Francisco, CA$202,500–$236,250 / yearLeveraging state-of-the-art machine learning technologies such as QSAR modeling, de novo design tools, and reaction prediction algorithms, you will develop robust workflows and processes that enhance compound design capabilities and enable data-driven decision-making. Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.
Principal Scientist, Purification Process Development Denali Therapeutics IncPrincipal Scientist, Purification Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Qualifications/Skills: Typically requires a PhD in Biology, Biochemistry, Chemical Engineering or related scientific discipline, plus 10+ years' of related work experience.
Principal Scientist - Generative AI Research | RD5004 Convai Technologies Inc.Principal Scientist - Generative AI Research | RD5004CAFocusing on new technologies for Speech Synthesis (TTS) and Large Language Models (LLM) Training large language models and monitoring data processing pipelines. Focusing on research publications and participating in conferences with an aim to partner with leading Deep Learning & AI researchers and industrial research labs.
Sr. Principal Scientist, Clinical Operations Immunology Lead Merck & Co IncSr. Principal Scientist, Clinical Operations Immunology LeadSouth San Francisco, CA$210,400–$331,100 / yearIn a competitive external landscape and fast-paced internal environment, the Immunology Clinical Operations Lead position provides both strategic and operational leadership across early immunology programs, ensuring timely, high-quality execution of clinical studies and clinical pharmacology strategies worldwide. Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients.