Principal/Sr. Principal Scientist - Development Genentech IncPrincipal/Sr. Principal Scientist - DevelopmentSouth San Francisco, CA$141,500–$262,900 / yearThe successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech's oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics. Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
Principal Scientist, Lab Head, Metabolism Drug Discovery Genentech IncPrincipal Scientist, Lab Head, Metabolism Drug DiscoverySouth San Francisco, CA$143,200–$265,900 / yearInterdisciplinary Collaboration: Partner closely with internal teams across departments and disciplines, including Drug Development, Translational Medicine, Transcriptomics/Proteomics, Computational and Clinical Science, to drive innovative therapeutic strategies, formulate new therapeutic hypotheses and advance transformative medicines. Key Responsibilities and Attributes of the Principal Scientist: Lab focused and biology driven, building and managing a team (approximately 2-3 direct reports) of expert experimental biologists focused on cardiovascular and renal disease biology, target and drug discovery.
Senior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of Excellence Genentech IncSenior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of ExcellenceSouth San Francisco, CA$130,800–$242,800 / yearThe Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness this transformative power of data and Artificial Intelligence (AI) to assist our scientists in delivering more innovative and transformative medicines for patients worldwide. The expected salary range for this position based on the primary location of South San Francisco, California is $130,800 - $242,800 (Senior Scientist) and $150,700 - $279,900 (Principal Scientist).
NewPrincipal Scientist, ML – Overall Architect AdobePrincipal Scientist, ML – Overall ArchitectSan Jose, CaliforniaAdobe’s industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity. End-to-End Architecture Ownership Own the overall technical architecture spanning the Training & Inference Framework, ML model building, and data — making principled design decisions that keep training systems, model architecture, and data pipelines coherent and mutually reinforcing.
NewPrincipal Scientist, ML - Overall Architect ADOBE IncPrincipal Scientist, ML - Overall ArchitectSan Jose, CA$261,800–$379,100 / yearAdobe's industry-leading offerings including Adobe Acrobat Studio, Adobe Express, Adobe Firefly, Creative Cloud, Adobe Experience Platform, Adobe Experience Manager, and GenStudio enable people and businesses to turn ideas into impact, powered by AI and driven by human ingenuity. End-to-End Architecture Ownership Own the overall technical architecture spanning the Training & Inference Framework, ML model building, and data - making principled design decisions that keep training systems, model architecture, and data pipelines coherent and mutually reinforcing.
Principal Scientist - Data Insights & Hypothesis Design TempusPrincipal Scientist - Data Insights & Hypothesis DesignRedwood City, CA$150,000–$200,000 / yearData Engineering & Scale Architecture: Proven experience collaborating directly with data engineering and platform teams to build large-scale relational databases, design advanced SQL data models, and support the robust infrastructure needed to create and deploy massive, production-grade models. Multi-Omic & NGS Modalities: Deep expertise executing multi-omic analyses across a diverse spectrum of high-throughput sequencing applications and biotechnologies, including specialized NGS modalities such as single-cell sequencing, immunomics, metagenomics, and varied sequencing platforms.
Principal Scientist, Immunology Jade BiosciencesPrincipal Scientist, ImmunologySan Francisco, CaliforniaRemote$175,000–$190,000 / yearThis role will provide scientific leadership across immunology-driven research activities that support Jade’s pipeline programs, including mechanism-of-action studies, disease biology assessment, indication evaluation, and translational strategy. Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs.
Principal Scientist - Data Insights & Hypothesis Design Tempus AI IncPrincipal Scientist - Data Insights & Hypothesis DesignRedwood City, CA$150,000–$200,000 / yearData Engineering & Scale Architecture: Proven experience collaborating directly with data engineering and platform teams to build large-scale relational databases, design advanced SQL data models, and support the robust infrastructure needed to create and deploy massive, production-grade models. Multi-Omic & NGS Modalities: Deep expertise executing multi-omic analyses across a diverse spectrum of high-throughput sequencing applications and biotechnologies, including specialized NGS modalities such as single-cell sequencing, immunomics, metagenomics, and varied sequencing platforms.
Principal Scientist, Drug Substance-Process Science/Immunology Allogene TherapeuticsPrincipal Scientist, Drug Substance-Process Science/ImmunologySouth San Francisco, CA$155,000–$180,000 / yearLed by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease.
Principal Scientist, Drug Product Process Science Allogene TherapeuticsPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
Principal Scientist, Drug Product Process Science Allogene Therapeutics IncPrincipal Scientist, Drug Product Process ScienceSouth San Francisco, CA$155,000–$180,000 / yearThe successful candidate will play a critical role in drug product process characterization and BLA readiness for allogeneic CAR-T therapies, including but not limited to process characterization design and execution, and regulatory‑ready documentation in support of BLA‑enabling and BLA submission activities, and will work closely with cross‑functional partners across MSAT, Quality, Regulatory, Analytical Sciences, and Clinical Operations. Experience working in the pharmaceutical or biotechnology industry that includes elements of new product development, process characterization, formulation development, equipment design and implementation, technology transfers, statistical process control (SPC), and statistical design and analysis of experiments.
NewAssociate Principal Scientist, Discovery Oncology, Reverse Translation Merck & Co IncAssociate Principal Scientist, Discovery Oncology, Reverse TranslationSouth San Francisco, CA$159,600–$251,200 / yearRequired Skills: Biology, Cancer Biology, Cancer Therapy, Cell Biology, In Vitro Pharmacology, In Vitro Research, Molecular Biology, Oncology, Preclinical Research, Target Validation, Tumor Biology, Tumor Models. This role is an exciting opportunity to contribute to reverse translation efforts that leverage clinical insights, in vitro systems, and in vivo oncology models to identify novel therapeutic targets and elucidate mechanisms of tumor biology, disease progression, and therapeutic response.
Principal Scientist, Drug Substance-Process Science/Immunology Allogene Therapeutics IncPrincipal Scientist, Drug Substance-Process Science/ImmunologySouth San Francisco, CA$155,000–$180,000 / yearLed by a management team with significant experience in cell therapy, Allogene is developing a pipeline of "off-the-shelf" CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. About Allogene: Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease.
Principal Scientist, Discovery Chemistry - San Carlos, California BeOne Medicines AGPrincipal Scientist, Discovery Chemistry - San Carlos, CaliforniaSan Carlos, CA$165,300–$206,600 / yearGeneral Description: At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location.
Principal Scientist, Immunology and Immuno-oncology - San Carlos, California BeOne Medicines AGPrincipal Scientist, Immunology and Immuno-oncology - San Carlos, CaliforniaSan Carlos, CA$198,000–$247,500 / yearEssential Functions of the Job: Identify and advance high-value therapeutic targets across immunology, inflammation and immuno-oncology therapeutic areas, aligned with organizational strategy, portfolio priorities and emerging scientific opportunities. Lead the design and execution of rigorous in vitro, ex vivo, and in vivo studies to validate target biology, establish disease rationale, evaluate therapeutic modalities, develop mechanistic insight, and generate decision-enabling data packages.
Senior Principal Scientist, Pharmacokinetics Merck & Co IncSenior Principal Scientist, PharmacokineticsSouth San Francisco, CA$194,100–$305,600 / yearThe successful candidate will provide scientific leadership for conjugate DMPK strategy, oversee LM ADME experimentation strategy and capabilities, contribute to portfolio management and prioritization, serve as a program representative in high priority programs and manage a team of principal investigators and biologics scientific experts. The South San Francisco DMPK organization is seeking an accomplished and highly collaborative Senior Principal Scientist to provide scientific leadership across drug conjugate discovery and development programs, support strategic portfolio decisions, and advance DMPK capabilities for emerging modalities.
Senior Principal Scientist -Bioanalytical Assay- Cell Therapy Genentech IncSenior Principal Scientist -Bioanalytical Assay- Cell TherapySouth San Francisco, CAD. in Immunology, Cell Biology, Biochemistry, Pharmacology, Bioanalytical Sciences, or a related life sciences discipline with a minimum of 7 years' experience in the field of drug discovery or development with extensive biopharmaceutical industry experience leading bioanalytical strategy across discovery, translational research, and clinical development. Opportunity: As an integral member of our dynamic team, you will: Define and drive the bioanalytical strategy supporting the Cell Therapy portfolio, establishing integrated, fit-for-purpose data strategies that generate the evidence needed to answer key scientific questions and inform development and portfolio decisions.
Principal Scientist Recruiting From ScratchPrincipal ScientistSan Francisco, CaliforniaWe're representing a dynamic company in the consumer healthcare and life sciences sector that is focused on developing innovative solutions for cleaner and safer products. This organization is committed to advancing research and applied science, fostering a collaborative environment where creativity and scientific rigor thrive.
Principal Scientist, Bioinformatics Nkarta IncPrincipal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Senior / Principal Scientist, Foundation Models for life Sciences Lila Sciences IncSenior / Principal Scientist, Foundation Models for life SciencesSan Francisco, CA$268,000–$384,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.