Principal Thermal Mechanical Engineer FlexPrincipal Thermal Mechanical EngineerLittleton, MassachusettsThe Principal Mechanical Engineer will provide technical leadership, mentorship, and hands-on expertise in mechanical design, fluid dynamics, and heat transfer but also work closely with customers in communicating the art of the possible with JetCool technology and building a strong customer relationship on a technical level. Lead the initial design, analysis, and optimization of complex fluid systems from concept initial CAD to final detailed CAD and drawing for liquid cooling, including cold plates, pumps, fluids, tubing, and heat exchangers, for the latest computer processing chipsets.
Principal Data Scientist - Gen AI Xometry IncPrincipal Data Scientist - Gen AIWaltham, MA$200,000–$230,000 / yearIn this role, you will serve as a technical leader, owning a 12 month technical roadmap, driving large-scale cross-functional ML and AI initiatives, and setting the long-term scientific direction for AI-driven solutions that enhance Xometry''s service offerings. Generative AI Development: Develop and deploy generative AI models and large language models (LLMs) for multimodal document processing, focusing on extracting structured data from technical drawings, purchasing orders, and other complex documents.
Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Principal Mobile Software Engineer Lumeris Inc (Inactive)Principal Mobile Software Engineermassachusetts, MA$143,190–$194,467.50 / yearProvides expertise and guides in all phases of the Agile software development life-cycle while working with cross-functional teams in a highly collaborative environment (Product team, Engineers, Development Leads, Architects, Quality Engineers, etc.). Position Summary: Designs, develops, documents, enhances, tests, and debugs extremely complex new and existing software systems and/or applications (cloud, network, internet, or in-house).
Associate Principal/Ediscovery (Forensic Services) CRA International, Inc.Associate Principal/Ediscovery (Forensic Services)Boston, MA$140,000–$170,000 / yearYour responsibilities may include (but are not limited to): Executing on projects involving the identification, collection, processing, review, and production of data relevant to litigation or regulatory investigations; Supporting engagement planning - participating in project team execution, analysis, and work product; Interfacing with client personnel and implementing client discovery strategies; Preparing client communications/reports for project milestones and senior leadership; Implementing client data processing projects, including planning of processing specifications, search parameters, etc. Ability to effectively lead teams, prioritize multiple projects, design workflows, and meet timely deadlines; Strong policy, process and project management experience, including management of multiple simultaneous workflows and team members; Excellent analytical, decision making and problem-solving skills; Ability to influence colleagues and implement initiatives across functions; Demonstrates integrity, initiative and commitment in all interactions with colleagues and clients.
Sr. Principal Lead Health Actuary Consultant Marsh & McLennan Companies, Inc.Sr. Principal Lead Health Actuary ConsultantBoston, MA$150,000–$225,500 / yearWe will count on you to: Lead routine client engagements, including managing overall service delivery, strategy, financial evaluations, plan design, renewal, business placement, benchmarking and other projects associated with underwriting health and welfare insurance, brokering contracts or projecting health care related costs. Principal Lead Health Actuary Consultant, you'll manage client projects focused on employers' health benefits strategies, including financial projections, carrier selection, plan design optimization, employee contribution setting, IBNP valuations, benchmarking, well-being initiatives, and renewal negotiations.
Principal Front Office Engineer, Investment Innovation, Integration & Trading Liberty Mutual Holding Company IncPrincipal Front Office Engineer, Investment Innovation, Integration & TradingBoston, MAAs a Principal Front-Office Engineer, you will serve as the technical lead embedded within the Investment Innovation, Integration & Trading (I3T) team, driving design and implementation of small-scale proofs of concept and prototypes that support the fixed income portfolio, improve investment analysis, develop AI-enabled workflows, and enhance reporting systems & processes. You will partner closely with analysts and investment teams to enhance their day-to-day use of AI, helping them build artifacts in a more technically sound manner and building robust systems and tools that scale those prototypes into production-ready applications.
Principal Software Engineer, Platform Engineering ModernaTXPrincipal Software Engineer, Platform EngineeringCambridge, MassachusettsThis is a senior individual contributor role that combines deep technical execution with cross-functional technical leadership across developers ("Builders"), Cybersecurity, Architecture, AI platform teams, and broader teams to provide scalable, secure, and user-focused capabilities that make the right path the easiest path for Moderna’s engineering teams. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Scientist, Systems and Disease Biology SanofiPrincipal Scientist, Systems and Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Principal AI Security Specialist - East Zscaler IncPrincipal AI Security Specialist - EastMARemote$175,875–$251,250 / year10+ Years of Solutions Engineering Mastery: A proven track record in a customer-facing technical role (Sales Engineering, Solutions Architecture, or Technical Advisory) navigating complex, enterprise-level sales cycles. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all US locations and could be higher or lower based on a multitude of factors, including job-related skills, experience, and relevant education or training.
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison Merck & Co IncSr. Principal Scientist (Sr. Director) - Regulatory LiaisonBoston, MA$190,800–$300,300 / yearRequired Skills: Biological Sciences, Clinical Reporting, Drug Development, Global Health, In Vitro Diagnostics (IVD), Multiple Therapeutic Areas, Pharmaceutical Regulatory Affairs, Process Improvements, Product Approvals, Regulatory Affairs Compliance, Regulatory Affairs Management, Regulatory Communications, Regulatory Compliance, Regulatory Issues, Regulatory Strategies, Regulatory Strategy Development, Written Communication. As the Global Regulatory Lead (GRL), the Senior Principal Scientist functions as the regulatory single, accountable, global point of contact on the project team and interacts with the global regulatory agencies and/or subsidiaries with regard to global regulatory strategy/registration requirements for one or more company investigational and marketed drugs/biologics in early- and/or late-stage development.
NewPrincipal Product Designer VIAPrincipal Product DesignerSomerville, MassachusettsRemote$160,000–$190,000 / yearAgentic and collaborative workflow experience: You've navigated UX problems where multiple users or multiple agents interact with shared state, and you know how to make those flows feel clear, not chaotic. Own end-to-end UX/UI design across VIA's product suite, including AI-native platforms, agentic workflow interfaces, multiplayer and collaborative data environments, and permission-controlled data sharing experiences.
NewBusiness Engagement & Technology Principal Analyst Vertex PharmaceuticalsBusiness Engagement & Technology Principal AnalystBoston, Massachusetts$142,800–$214,200 / yearThis individual will partner closely with commercial stakeholders and technology teams to define business needs, improve processes, and enable scalable digital capabilities that support scaling operations, order management, analytics, and end to end patient journey across multiple platforms and technologies. Vertex is seeking a Principal Business Analyst, Cell & Gene Therapy Commercial Technology to join the Data, Technology and Engineering (DTE) team and play a key role in shaping and supporting technology solutions for our Cell & Gene Therapy commercial organization.
Pharmacology Principal Research Associate Vertex Pharmaceuticals, IncPharmacology Principal Research AssociateBoston, MA$89,800–$134,800 / yearThe ideal candidate will also have hands-on experience with basic in vivo techniques, including animal handling, dosing via multiple routes of administration (ROAs), perfusion, biofluid collection, tissue dissection/processing, and basic bioanalytical assays such as ELISA using serum and urine samples. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Principal Consultant Appian CorpPrincipal ConsultantBoston, MA$100,000–$225,000 / yearKnowledge of software testing practices (test-driven development, automated test suites within a continuous integration framework); integrations experience using APIs such as REST and SOAP, JDBC connections, and web services; familiarity with Amazon Web Services (AWS), Artificial Intelligence (AI), Analytics, Machine Learning, Google Cloud, Application Integration, Database, Developer Tools, Management & Governance, and Elastic Containers is preferred. This includes working within an agile environment to understand our client's business processes and technical needs, launch new relational data models in production, developing APIs to integrate with multiple systems, partnering with Appian Architects and Technical Delivery Managers, and leading/mentoring consultants through fast-paced software implementations.
Principal Scientist, Dmpk Alnylam Pharmaceuticals, Inc.Principal Scientist, DmpkCambridge, MAThe candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance programs from discovery through clinical development. Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership teams to integrate PK, PD, efficacy, safety, and biomarker data and inform development decisions.
Principal Specialist, Security - Andover, MA RTXPrincipal Specialist, Security - Andover, MAMassachusettsThis is a Principal Specialist, Security position responsible for providing a range of security actions to support the Andover location in the areas of Document Control, Security Education and Awareness Training providing policy/process guidance, support security investigations and participate in the DGR process involving exports. Interpret company policies and government regulations and provide guidance and assistance to program and functional partners, prepare for and support DCSA and self inspection activities and ensure continuity and coverage of Document Control operations providing surge support.
Data Backups System Administrator, Principal Specialist, Woburn, MA Onsite RTXData Backups System Administrator, Principal Specialist, Woburn, MA OnsiteWoburn, MassachusettsThe Raytheon Digital Technology Storage & Data Protection team requires a seasoned administrator (P3 level) who will be responsible for backing up classified data from NetApp systems and client machines to tape for off‑site archival. The Storage & Data Protection Backup Administrator plays a key operational role in maintaining reliable tape‑based archival processes, enabling secure long‑term retention of critical program information.
Finance Principal Specialist RTXFinance Principal SpecialistConcord, MassachusettsAt Raytheon Missiles & Defense, you have the opportunity to try new things and make a bigger difference across a broader end-to-end solution, a richer technology and product set, an expanded range of disciplines, a growing global footprint and a growing team of colleagues and customers. In addition, this position requires wide-ranging financial support and analysis across Engineering, FP&A and the SBUs regarding project health & prioritization, manpower forecasting, process improvement and overall management of business-related tasks.
Principal Integrated product Team (IPT) Lead RTXPrincipal Integrated product Team (IPT) LeadMassachusettsMinimum of 8 years of experience with technical projects, Previous Integrated Product Team (IPT) Lead or Program Management experience and experience in semiconductor design, fabrication, or testing and/or RF module development. As part of our commitment to maintaining a secure hiring process, candidates may be asked to attend select steps of the interview process in-person at one of our office locations, regardless of whether the role is designated as on-site, hybrid or remote.