NewPrincipal Scientist, Pharmacokinetics Merck & Co IncPrincipal Scientist, PharmacokineticsBoston, MA$176,200–$277,300 / yearThe ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities (small molecules, peptides, protein therapeutics) as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Contribute to global DMPK strategy and implementation of cutting-edge ADME science through close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidates.
NewPrincipal Electrical Engineer Re:Build ManufacturingPrincipal Electrical EngineerWilmington, MA$165,000–$250,000 / yearAn experienced engineering leader with a broad range of electrical engineering disciplines, including analog and digital circuit design, power electronics, PCB design, sensors, instrumentation, embedded electronics, and electromechanical systems. We operate an advanced, end-to-end manufacturing platform that partners with industrial companies and innovators to take products from first concept to full-scale production in critical verticals including aerospace and defense, electrification, medical, energy and environment, and robotics and automation.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearDesign, build, and integrate real-time embedded software for Lexington Medical's surgical stapling platform and supporting devices, primarily using ARM Cortex-M or equivalent microcontroller-based systems. With engineering, manufacturing, and quality working closely together, engineers stay close to the product and see their work move from an idea through prototyping, testing, manufacturing, and ultimately into the operating room.
Principal Controls and Automation Engineer Michael Page InternationalPrincipal Controls and Automation EngineerBillerica, Massachusetts$180,000–$200,000 / yearFull timeBachelor's degree in Electrical Engineering, Controls Engineering, Automation Engineering, or a related technical discipline. The organization is driving innovation in energy storage manufacturing through proprietary technologies that improve efficiency, scalability, and sustainability.
Sr. Principal Scientist / Director, DMPK & Bioanalytical Sciences AlltrnaSr. Principal Scientist / Director, DMPK & Bioanalytical SciencesCambridge, MA$213,000–$280,500 / yearThe company's initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affects approximately 10% of people with a rare genetic disease. Reporting to the Chief Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical programs, operating as a hands-on scientific leader.
Electrical Engineer (Senior/Staff/Principal) NanopathElectrical Engineer (Senior/Staff/Principal)Cambridge, MAWe aim to replace lengthy molecular testing workflows by bringing rapid, high-quality diagnostics closer to the patient. At Nanopath we are dedicated to building a diverse and inclusive workplace, so if you’re excited about this role but your past experience doesn’t align perfectly with every point in the job description, we encourage you to apply anyways.
Senior / Principal Scientist Analytical Method Development Lead Terrestrial Bio IncSenior / Principal Scientist Analytical Method Development LeadWoburn, MA$125,000–$180,000 / yearThis individual will lead the development of release and characterization methods including HPLC/UPLC, LC-MS, and functional assays and own the analytical method lifecycle from Phase 2 through Phase 3 IND and commercialization. This is a senior technical leadership role for a scientist with deep peptide/biologic analytical expertise and a track record of building robust, regulatory-compliant methods.
Principal Cloud Data Engineer (Teradyne, North Reading, MA) Teradyne IncPrincipal Cloud Data Engineer (Teradyne, North Reading, MA)North Reading, MARemote$179,700–$287,500 / yearYou will engineer the ingestion, transformation, and serving layers that ground our AI platforms-including Azure AI Foundry, Microsoft Copilot Studio, Google Vertex AI, and Snowflake Cortex AI-in high-quality proprietary data, while leveraging Informatica for data governance, data quality, and application integration, and Semarchy for master data management. 8-10 years of experience in data engineering, with the last 2-3 years focused on modern cloud data engineering projects that enable AI products and analytics (cloud data warehouse/lakehouse, ELT, and pipeline automation).
Sr. Principal Scientist, Nonclinical Drug Safety Merck & Co IncSr. Principal Scientist, Nonclinical Drug SafetyBoston, MA$190,800–$300,300 / yearStrategically influence nonclinical drug safety considerations for Immunology programs by providing drug development mentorship and partnering with Compound Leaders on time-critical matters, including nonclinical program design and toxicology study design, weight-of-evidence risk assessments, science-based waiver strategies, and integrated safety development plans that support clinical trials, global registration, and timely resolution of nonclinical development issues. Provide scientific and strategic oversight for Immunology candidates through close collaboration with Program Coordinators, Discovery Preclinical Leaders, Compound Leaders, and scientists across NDS and/or Preclinical Development, while ensuring strong partnership with key Research and Development Division functions, including Discovery, chemistry, regulatory affairs, translational medicine, clinical development, and CMC.
Principal, Fund Controller Partner's CapitalPrincipal, Fund ControllerBoston, Massachusetts$120,000–$170,000 / yearStrategic Partnership and Other: You will serve as a trusted advisor to global client CIOs, fund PMs, and research teams, ensuring fund finance considerations are integrated into broader strategic decisions. The Firm designs bespoke investment policies reflecting each client’s unique circumstances and implements investment solutions that aim to deliver strong returns with resilience across market cycles.
Principal Scientist (Scientific Director Level)- Nonclinical Drug Safety Merck & Co IncPrincipal Scientist (Scientific Director Level)- Nonclinical Drug SafetyBoston, MA$176,200–$277,300 / yearThey are responsible for 1) providing risk assessments for targets, 2) de-risking strategies for discovery programs and 3) collaborating with NDS staff at other sites to execute on the appropriate studies to support selection of therapeutic targets, and the identification and development of new drug candidates. The Discovery Program Leader is responsible for defining and overseeing the NDS strategy for programs in all modalities (including small molecules, peptides, biologics and ADC programs) from Target Identification through to the approval of First-In-Human enabling GLP toxicity studies.
Principal Systems Verification Architect (IST, North Reading, MA) Teradyne IncPrincipal Systems Verification Architect (IST, North Reading, MA)North Reading, MA$166,300–$266,100 / yearTeradynes Integrated Systems Test (IST) Hardware Engineering team is seeking a highly motivated, energetic and technically driven Senior Systems Engineer to deliver world-class System-Level Test solutions to a growing portfolio of customers. Multidisciplinary technical expertise in one or more of the following: complex electronic systems, network systems, embedded systems, automation and controls, thermal systems, power distribution, pneumatics, software usability or test execution.
Principal Mixed-Signal Design Engineer Analog Devices IncPrincipal Mixed-Signal Design EngineerWilmington, MA$157,080–$227,460 / yearACG has an excellent track record of producing breakthrough, innovative technologies including RF DACs and ADCs, and SerDes PHYs, in cutting-edge FinFET process technologies for integration into highly sophisticated system-on-chip (SoC) products. ADI combines analog, digital, AI, and software technologies into solutions that combat climate change, reliably connect humans and the world, and help drive advancements in automation and robotics, mobility, healthcare, energy and data centers.
Principal, Program Execution Wellington Management Company LLPPrincipal, Program ExecutionBoston, MAYou will own the planning cycles and governance structures that connect firm priorities to how our seven Infrastructure functions operate, build reporting mechanisms that give the leadership team real visibility into outcomes, and bring a clear analytical mind to operating model questions as the business evolves. This part of the role is about ensuring AI enablement lands consistently across the seven functions, from tracking where adoption is happening and where it is lagging, to working with functional leaders to identify the use cases with the most practical value and helping connect them to the tools, training, and governance they need to move forward.
Sr. Principal Or Engineering Advisor - Agentic Lab Automation Integration Eli Lilly and CompanySr. Principal Or Engineering Advisor - Agentic Lab Automation IntegrationBoston, MA$87,000–$222,200 / yearOur current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). This is a hands-on engineering role: you'll prototype rapidly, productionize what works, and collaborate with chemists, biologists, and automation engineers to deploy intelligent systems that accelerate molecule discovery tasks.
SAP EWM- Principal Solution Architect Capgemini SESAP EWM- Principal Solution ArchitectBurlington, MA$123,750–$326,250 / yearAs a trusted advisor and solution leader, you will partner with business and technology stakeholders to design scalable warehouse management solutions aligned to SAP S/4HANA, Transportation Management (TM), and broader Demand-to-Supply (DTS) business processes. As a SaaS Solution Architect, you will bring your SaaS - and also non-SaaS - technology capabilities to architect solutions, converting business ambitions into Multi-Pillar SaaS architectures that enable agile, flexible and end-to-end business outcomes.
Principal Fullstack Engineer (AI) - Boston PragmatikePrincipal Fullstack Engineer (AI) - BostonCambridge, MassachusettsThis role is ideal for an engineer who enjoys owning features end to end—from backend architecture to polished frontend delivery—someone who can design APIs, build scalable services, craft intuitive user interfaces, and ship production-ready features at scale. We are searching for a Senior Full Stack Engineer (Node.js + React) with strong hands-on experience building scalable, high-performance web applications powering complex, data-intensive AI products used by Fortune 500 customers.
Sr. Principal or Engineering Advisor - Agentic Lab Automation Integration Eli Lilly and CoSr. Principal or Engineering Advisor - Agentic Lab Automation IntegrationBoston, MA$87,000–$222,200 / yearOur current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). This is a hands-on engineering role: you'll prototype rapidly, productionize what works, and collaborate with chemists, biologists, and automation engineers to deploy intelligent systems that accelerate molecule discovery tasks.
Principal Quality Development Engineer InterSystems CorpPrincipal Quality Development EngineerBoston, MA$115,000–$164,000 / yearBuilt on InterSystems' health informatics platform, HealthShare, TrakCare and IntelliCare create a consolidated view of each patient's history, provide secure access to records at every point of care and on any Internet-connected device, enables interoperability with legacy and future applications, and perform analytics that provide real-time insights to drive fully informed actions. About the Product: Healthcare organizations in 25 countries are making breakthroughs in patient care with TrakCare and IntelliCare, a unified healthcare information system that enables coordinated care within a hospital or across care settings throughout a region - facilitating a seamless patient journey.
Principal Systems Developer - Kernel InterSystems CorpPrincipal Systems Developer - KernelBoston, MA$144,000–$205,000 / yearAt its core is a super scalable, high performance database engine built to naturally and flexibly store data accessed from multiple data models, including multi-dimensional arrays, key/value, relational tables, and objects. The database kernel team needs a creative and motivated developer to join them in designing, implementing and enhancing components of the database engine and its embedded programming language.