San Francisco, CA30+ days ago
PROTACs or other IPMs)Contributing to hit-to-lead and lead optimization studiesMed-chem optimizations: SAR, PK/PD, strong understanding of DMPKApplicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistryNice to have:Proficiency in HTS and phenotypic assay developmentProteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc. Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.