Principal Scientist, Toxicology 6084-Janssen Research & Development Legal EntityPrincipal Scientist, ToxicologySpring House, PennsylvaniaThe candidate will contribute to the success and growth of PSTS through active participation in internal and external committees / working groups and will closely interact with scientists in other functional areas including pathology, bioanalysis, toxicokinetics, and development project leaders in the US, Belgium, and China. Strong written and verbal communication skills and the ability to negotiate and influence decision-making processes, think and manage issues to resolution, and contribute to study teams and scientific discussions are required with prior experience in scientific data evaluation, integrated safety assessment, and scientific writing.
Principal Scientist, Early Development ADSI 6084-Janssen Research & Development Legal EntityPrincipal Scientist, Early Development ADSIMalvern, PennsylvaniaAnalytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research The Principal Scientist, Early Development Analytical Development Scientific Integrator (ADSI) will be responsible for the following: Provide strategic and technical leadership in analytical development and lead a cross-functional scientific team consisting of members from each of the AD sub-functions.
Senior Principal Scientist, Biologics Discovery Process Research Integrator 6084-Janssen Research & Development Legal EntitySenior Principal Scientist, Biologics Discovery Process Research IntegratorSpring House, PennsylvaniaAnalytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Collaboration, Data Synthesis, Drug Discovery Development, Molecular Diagnostics, Pharmacovigilance, Process Improvements, Productivity Planning, Program Management, Scientific Research, Tactical Planning, Technical Credibility Building trusted cross‑functional partnerships and influencing decision‑making across Therapeutics Discovery (TD), Preclinical Sciences & Translational Safety (PSTS), Therapeutic Areas (TAs), and TDS in matrixed governance and technical forums.
Senior Principal Scientist, Biologics Discovery Process Research Integrator – Protein Expression and Scale-Up 6084-Janssen Research & Development Legal EntitySenior Principal Scientist, Biologics Discovery Process Research Integrator – Protein Expression and Scale-UpSpring House, PennsylvaniaAnalytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Collaboration, Data Synthesis, Drug Discovery Development, Molecular Diagnostics, Pharmacovigilance, Process Improvements, Productivity Planning, Program Management, Scientific Research, Tactical Planning, Technical Credibility The role will provide integrative technical leadership grounded in mammalian expression, cell line development, and scale-up expertise, ensuring that expression feasibility, manufacturability, productivity, product quality, and scalable production considerations are incorporated into molecule selection, material supply planning, and program strategy.
Senior Principal Architect, Solution Architecture Cencora, Inc.Senior Principal Architect, Solution ArchitectureConshohocken, PAPartners closely with product, engineering, and business stakeholders to ensure technology investments are prioritized and delivered with a product ownership mindset focused on measurable business outcomes. Summary: Defines enterprise solution architecture direction across interdependent domains, translating long-term business and technology strategy into scalable, secure, resilient, and supportable solution approaches.
Principal Designer, Product Design Cencora, Inc.Principal Designer, Product DesignTrenton, NJ$110,500–$220,990 / yearSummary: The Principal Designer, Product Design is the founding leader of the discovery and research function within MSO Technology Solutions, responsible for building the operating model that will define how the team understands, validates, and prioritizes problems across the MSO unified technology platform. The Principal Designer partners closely with Product Management, Architecture, Engineering, Data & Analytics, Practice Leadership and Physicians to ensure that every major platform initiative is grounded in validated practice needs and tied to measurable outcomes.
Principal Engineer, Software Engineering - Ecommerce Applications Cencora, Inc.Principal Engineer, Software Engineering - Ecommerce ApplicationsConshohocken, PA$110,500–$220,990 / yearPosition Summary: The Principal Engineer, Software Engineering - eCommerce and Portal Applications is a senior technical leader responsible for driving the design, development, modernization, and operational excellence of enterprise eCommerce and portal platforms. This position plays a critical role in shaping engineering direction, enabling delivery teams, and ensuring digital platforms support seamless customer, partner, and internal user experiences.
Principal Architect, Security Architecture Cencora, Inc.Principal Architect, Security ArchitectureConshohocken, PALeads architectural decisions related to Identity Governance and Administration (IGA), Privileged Access Management (PAM), Single Sign-On (SSO), Multi-Factor Authentication (MFA), Passwordless Authentication, Identity Federation, and Access Governance. The Principal IAM Architect partners with cybersecurity, infrastructure, application development, cloud engineering, and business leaders to design scalable identity solutions that support business growth, regulatory compliance, and Zero Trust security objectives.
NewPrincipal Cyber Def Threat Intell Analyst ExelonPrincipal Cyber Def Threat Intell AnalystPHILADELPHIA, PAWe are a Fortune 200 company, 20,000 colleagues strong serving more than 10.7 million customers at six energy companies -- Atlantic City Electric (ACE), Baltimore Gas and Electric (BGE), Commonwealth Edison (ComEd), Delmarva Power & Light (DPL), PECO Energy Company (PECO), and Potomac Electric Power Company (Pepco). The Principal Cyber Defense Threat Intelligence Analyst (CDTIA) identifies, collects, and monitors appropriate threat intelligence information from various sources to analyze, synthesize, and provide actionable intelligence reports and briefings to the joint security operations center (JSOC) and other information technology (IT) and operational technology (OT) teams.
NewPrincipal Engineer Wells Fargo & CoPrincipal EngineerWILMINGTON, DE$175,000–$279,000 / yearThey are accountable for execution of all applicable risk programs (Credit, Market, Financial Crimes, Operational, Regulatory Compliance), which includes effectively following and adhering to applicable Wells Fargo policies and procedures, appropriately fulfilling risk and compliance obligations, timely and effective escalation and remediation of issues, and making sound risk decisions. Lead the strategy and resolution of highly complex and unique challenges requiring in-depth evaluation across multiple areas or the enterprise, delivering solutions that are long-term, large-scale and require vision, creativity, innovation, advanced analytical and inductive thinking.
NewChief Engineer/Principal Software Engineer CACI International Inc.Chief Engineer/Principal Software EngineerKing Of Prussia, PA$114,600–$252,100 / yearLeadership Track Record: Proven experience as a Chief Engineer or senior technical delivery leader guiding large-scale teams (35+ personnel) through full SDLC in classified environments (Note: architectural vision is covered by our Chief Architect, so this role centers on execution, delivery, and team enablement). Stakeholder Engagement: Serve as a primary technical interface to leadership, government customers, and subcontractor teams, leading Technical Exchange Meetings (TEMs) and aligning execution with mission goals.
NewPrincipal Ai/Ml Engineer (Large Language Model) CACI International Inc.Principal Ai/Ml Engineer (Large Language Model)Philadelphia, PA$114,600–$252,100 / yearExperience leading an interdisciplinary team of researchers and software developers and working with a program manager to define project scope and schedule to ensure we meet project milestones as defined by our customers. Pay Range: There are a host of factors that can influence final salary including, but not limited to, geographic location, Federal Government contract labor categories and contract wage rates, relevant prior work experience, specific skills and competencies, education, and certifications.
NewSr. Principal Designer, CATS & SPECS Piping KBR IncSr. Principal Designer, CATS & SPECS PipingNewark, DEKBR ISA (Integrated Solutions Americas) delivers integrated, end-to-end engineering, procurement, and construction management services to the refining, LNG, midstream, chemicals, petrochemicals, oil and gas, power, and industrial infrastructure sectors. Required Education, Experience, & Skills: Minimum of 10 years of experience developing and maintaining piping catalogs and specifications for industrial, energy, chemical, refining, LNG, or related projects.
NewPrincipal CRA ICON PlcPrincipal CRABlue Bell, PACollaborating with cross-functional teams, including clinical project managers, data managers, and biostatisticians, to ensure the successful execution of clinical trials. Key responsibilities include: Leading site management activities, including site selection, initiation, monitoring, and close-out visits, to ensure compliance with study protocols and regulatory guidelines.
NewPrincipal Scientist, AI & Autonomous Discovery Systems - Spring House, PA Johnson & JohnsonPrincipal Scientist, AI & Autonomous Discovery Systems - Spring House, PASpring House, PennsylvaniaRemoteJohnson & Johnson Innovative Medicine is recruiting for a Principal Scientist, AI & Autonomous Discovery Systems, to advance AI-powered drug discovery through human-guided autonomous and agentic discovery platforms and help accelerate drug discovery by creating AI-enabled Design-Make-Test-Learn ecosystems that improve scientific decision quality, increase experimental throughput, reduce cycle times, and advance high-value therapeutic programs. Define the technical vision, long-term strategy, and scalable multi-agent architecture for AI-driven laboratory orchestration and human-guided autonomous discovery systems, coordinating scientific reasoning, knowledge retrieval, experiment planning, model execution, workflow automation, and decision support while influencing investments across discovery platforms, therapeutic areas, and enterprise AI initiatives.
Principal Data Scientist - Immunology - (2 positions) Johnson & JohnsonPrincipal Data Scientist - Immunology - (2 positions)Titusville, New JerseyRemoteWork with Data Science & Digital Health colleagues, IT and DevOps teams to deploy and manage the graph database infrastructure, focusing on high availability, scalability, and recovery operations specifically geared toward Immunology R&D needs and applications. Cambridge, Massachusetts, United States of America, Raritan, New Jersey, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America Job Description:
Senior Principal Scientist, Bioanalytical Outsourcing Johnson & JohnsonSenior Principal Scientist, Bioanalytical OutsourcingSpring House, PennsylvaniaClinical Pharmacology, Clinical Trials Operations, Consulting, Drug Discovery Development, Industry Analysis, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacometrics, Program Management, Report Writing, Researching, Research Proposals, Scientific Research, Tactical Planning, Technical Credibility The candidate will have a successful track record of problem solving, good organizational habits, excellent interpersonal skills, the ability to work under timelines, and the ability to collaborate within multidisciplinary teams is required.
Principal Scientist, High-Content Imaging Johnson & JohnsonPrincipal Scientist, High-Content ImagingSpring House, PennsylvaniaAdditional responsibilities include building and implementing data generation pipelines, troubleshooting complex experiments at the bench and across imaging platforms, optimizing protocols, analyzing imaging data, and collaborating with internal teams, CROs, and external technology partners to support capability development. The ideal candidate will be a hands-on technical contributor responsible for developing, validating, and deploying cutting-edge high-content imaging capabilities to advance therapeutic discovery across the Immunology, Neuroscience, and Oncology portfolios.
Principal Analyst, Advertising Regulation Financial Industry Regulatory Authority, Inc.Principal Analyst, Advertising RegulationPhiladelphia, PAFINRA employees are required to disclose to FINRA all brokerage accounts that they maintain, and those in which they control trading or have a financial interest (including any trust account of which they are a trustee or beneficiary and all accounts of a spouse, domestic partner or minor child who lives with the employee) and to authorize their broker-dealers to provide FINRA with duplicate statements for all of those accounts. Employees may only maintain securities accounts that must be disclosed to FINRA at one or more securities firms that provide an electronic feed (e-feed) of data to FINRA, and must move securities accounts from other securities firms to a firm that provides an e-feed within three months of beginning employment.
Oil And Gas/Energy Finance Managed Services, Principal Baker Tilly Virchow Krause, LLPOil And Gas/Energy Finance Managed Services, PrincipalPhiladelphia, PABaker Tilly Advisory Group, LP and Baker Tilly US, LLP, trading as Baker Tilly, are independent members of Baker Tilly International, a worldwide network of independent accounting and business advisory firms in 141 territories, with 43,000 professionals and a combined worldwide revenue of $5.2 billion. Baker Tilly is a leading advisory, tax and assurance firm, providing clients with a genuine coast-to-coast and global advantage in major regions of the U.S. and in many of the world's leading financial centers - New York, London, San Francisco, Los Angeles, Chicago and Boston.