May directly manage complex safety issues related to individual case review, risk management, translational medical safety, and aggregate safety reports, including: Ensure that adverse events are evaluated accurately and promptly, including clinical assessments to determine the seriousness, causality, and expectedness of the adverse event in relation to the drug. The Executive Director, Head of Center of Excellence (CoE), Global Medical Safety will oversee a team of safety physicians and scientists across various regions, offering guidance and support to each product safety team in critical areas such as individual case medical review, risk management, aggregate safety reports, and translational medical safety.