West Point, PA30+ days ago
The Translational PK/PD Scientific Director will: Serve as expert PK/PD modeler in cross-functional teams, to make model-informed decisions about drug discovery, modality selection, and dose prediction across therapeutic areas; Integrate in vitro and in vivo data to build PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms of drug disposition and pharmacology, to support forward / reverse translation for both established and novel therapeutic targets; Guide software developers in the design of automated workflows for implementing modeling platforms, to inform human PK/PD and dose projections; Collaborate across the PDMB organization to develop modeling and simulation strategies to identify and optimize drug candidates; Provide scientific guidance and cross-functional supervision to a team of growing scientists; Mentor / supervise junior colleagues to perform the above duties and to grow the above capabilities. Preferred: Demonstrated ability to lead interdisciplinary teams and to oversee the work of other scientists and software developers; Expertise in developing novel translational modeling strategies or automated workflows that rely on PBPK, QSP, or related mechanistic modeling.