2,020 Results for

Principal Jobs in Waltham, MA

Jobs

Principal Network Engineer Lila Sciences

Cambridge, Massachusetts

$171,000–$230,534 / year

As Principal Network Engineer, you will be the senior technical owner of that network: building the in-house engineering capability to design, secure, and scale it, while increasing the value and effectiveness of our managed service provider relationships. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.

3 days ago

Principal DevOps Engineer BitSight Technologies Inc

Boston, MA

Remote

$126,000–$180,000 / year

This range reflects the minimum and maximum target for new hire salaries for the position across all US locations, is based on a full-time work schedule, and is Bitsight's good faith estimate as of the date of this posting. Operate EKS clusters, including capacity planning, node and pod density, graceful shutdown, and access models that give developers the access they need.

5 days ago

Associate Principal- Corporate Strategy Advisory Trinity Life Sciences

Waltham, Massachusetts

$170,000–$234,000 / year

Trinity’s salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. Associate Principals have unique • opportunities to manage daily client interactions with full oversight over project teams – client management, project management, employee management, budget and financial management, and more.

9 days ago

Principal Scientist, R&D Data, Data Science & Artificial Intelligence - Immunology Johnson & Johnson

Cambridge, MA

Remote

$117,000–$201,250 / year

All Job Posting Locations: Cambridge, Massachusetts, United States of America, Raritan, New Jersey, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America. To successfully meet these objectives, this individual will work closely with clinical project teams and functional partners across Translational Science, Translational Medicine, Discovery, Late Development, Market Access, Medical Affairs, Data Platforms, Insights & Analytics, and other relevant functions.

5 days ago

Principal Gifts Officer WGBH Boston

Boston, MA

$110,630–$140,600 / year

The successful candidate will be a senior-level relationship builder with credibility in building a high-net worth pipeline for philanthropy They will have a proven record of identifying, qualifying and cultivating high-net-worth prospects, closing complex major and principal gifts, building lasting donor relationships, and partnering effectively with senior leaders, volunteers, and stakeholders to achieve ambitious fundraising goals. Through individual giving, major gifts, planned giving, institutional fundraising, corporate support, membership, and campaign fundraising, the department builds meaningful relationships with donors who share GBH's commitment to journalism, education, culture, and community engagement.

7 days ago

Underwriting Principal Fifth Third Bank

Boston, MA

$96,500–$207,500 / year

Responsible for identifying, assessing and communicating credit risks; performing detailed due diligence and financial analysis; and supporting sound underwriting decisions within established policies and risk appetite, with escalation of complex, sensitive or policy-exception transactions as required. The base salary for this position is reflective of the range of salary levels for all roles within this pay grade across the U.S. Individual salaries within this range will vary based on factors such as role, relevant skillset, relevant experience, education and geographic location.

4 days ago

Associate Principal Scientist, Clinical Research Merck & Co Inc

Boston, MA

$142,400–$224,100 / year

Experience developing, implementing, and managing immunology clinical programs and trials in healthy participants and/or patients to ensure efficient, timely execution against milestones under accelerated timelines; experience with immunology early patient trials (eg, Phase 1b patient trials in rheumatology, dermatology, and/or gastroenterology) preferred. Brief Description of Position: Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients.

8 days ago

Principal Seller McKinstry Co.

Boston, MA

$153,400–$229,400 / year

The ideal candidate is a high-energy, results-driven sales executive with a proven track record of closing large-scale DER deals, strong industry relationships, and the ability to strategically position McKinstry's solutions in a highly competitive landscape. This role is responsible for sourcing, structuring, and closing high-value DER projects, driving revenue growth, and expanding McKinstry's market share as a designer, builder and operator of DER projects across the eastern US.

5 days ago

Securities & Corporate Counsel (Senior / Principal level considered) Revvity

Waltham, Massachusetts

$146,000–$220,000 / year

Prepare and file Section 16 reports (Forms 3, 4, 5) for officers and directors, manage pre-clearance procedures, support the administration of Rule 10b5-1 trading plans and the company’s insider trading compliance program, and advise on equity compensation plan registrations and related securities filings. Support the preparation, review, and filing of periodic SEC reports (Forms 10-K, 10-Q, 8-K), proxy statements (DEF 14A), registration statements (Forms S-3, S-8), and other SEC filings, working with finance, accounting, and investor relations teams through each reporting cycle.

12 days ago

VP, Principal Resilience Engineer Chubb Ltd

Boston, MA

$158,550–$229,950 / year

Reporting to the Executive Vice President, Global Resilience and Risk Consulting, and working hand-in-hand with the Vice President, Community Resilience, the Principal Resilience Engineer will work across Chubb's risk consulting, underwriting, catastrophe modeling, claims, and analytics teams, as well as with external stakeholders, including property owners, developers, community associations, local governments, and utilities. The Principal Resilience Engineer will help communities understand what to do, help partners implement effective solutions, and help Chubb recognize meaningful risk reduction - supporting safer properties, stronger communities, and the responsible expansion of insurance in catastrophe-exposed markets.

6 days ago

Intelligence Center X Principal - Americas Mendix Technology BV

Boston, MA

$197,300–$394,600 / year

You lead the ideation and creation of our most strategic customer engagements - modelling complex domains as enterprise ontologies, designing agents and machine learning that reason over them and act on them, and delivering agentic applications that compel customers to invest in Intelligence Center X with Siemens. Engage executives and strategic partners - build and defend the business case with senior customer stakeholders, mobilize Siemens leadership, and lead strategic partnerships with GSIs, ISVs and hyperscalers.

7 days ago

Principal Game AI Engineer Take-Two Interactive Software Inc

massachusetts, MA

$180,000–$210,000 / year

Subject to those same considerations, the total compensation package for employees in regular roles may also include other elements, including a bonus and/or equity awards, in addition to a full range of medical, financial, and/or other benefits, provided that temporary or intern roles will not be eligible for many of these payments or benefits. Who We Are: Ghost Story Games is a self-publishing game development studio founded by Ken Levine (Creative Director of System Shock 2, Bioshock, and Bioshock Infinite) and former Irrational Games developers.

8 days ago

Principal Legal Counsel SS&C Technologies Holdings Inc

Boston, MA

$160,000–$215,000 / year

More than 23,000 financial services and healthcare organizations, from the world's largest companies to small and mid-market firms, rely on SS&C for expertise, scale, and technology. Prepare and oversee production of various mutual fund, ETF and closed-end fund regulatory filings with the U.S. Securities and Exchange Commission, including registration statements on Form N-1A and Form N-2.

7 days ago

Principal Product Designer VIA

Somerville, Massachusetts

Remote

$160,000–$190,000 / year

Own end-to-end UX/UI design across VIA's product suite, including AI-native platforms, agentic workflow interfaces, multiplayer and collaborative data environments, and permission-controlled data sharing experiences. Agentic and collaborative workflow experience: You've navigated UX problems where multiple users or multiple agents interact with shared state, and you know how to make those flows feel clear, not chaotic.

8 days ago

Principal DevOps Architect MKS Inc

Andover, MA

$140,000–$185,000 / year

Preferred Skills: Experience integrating Source Code Management, CI/CD Pipelines, DevSecOps tooling, secure artifact management, software supply-chain controls, and AI-assisted development capabilities into enterprise engineering workflows. You will partner directly with engineering teams, IT, and Security to architect and modernize our DevOps ecosystem, simplify a diverse tool landscape, create reusable engineering solutions, and establish platforms that teams can rely on.

5 days ago

Principal DevOps Engineer BitSight Technologies

Boston, Massachusetts

Remote

This range reflects the minimum and maximum target for new hire salaries for the position across all US locations, is based on a full-time work schedule, and is Bitsight’s good faith estimate as of the date of this posting. Operate EKS clusters, including capacity planning, node and pod density, graceful shutdown, and access models that give developers the access they need.

7 days ago

Principal Scientist, Target Binding Generate Biomedicines

Somerville, Massachusetts

The successful candidate will be an established industry expert in quantitative biophysical assay development, particularly for challenging systems such as integral membrane proteins, lipid- associated targets, detergent-solubilized proteins, and multispecific molecules. This individual will provide scientific and strategic leadership for protein–protein interaction, target-binding, and cell-binding measurements across multiple biotherapeutic discovery and development programs.

12 days ago

Principal Associate Scientist, Analytical Development & Operations Strand Therapeutics Inc

Boston, MA

$105,000–$114,000 / year

Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Primary Responsibilities: Leads development of analytical methods or novel analytical techniques focusing on deep physical characterization of early/clinical-stage mRNA and LNP formulations.

7 days ago

Principal Software Engineer (Sre & Architecture) Sophia Genetics

Boston, MA

$88,000–$168,000 / year

We know that every background is different, but to be best set for success we see you bringing: Significant hands-on experience designing, building, testing and operating full-stack web applications and services in production, with 5-7 years of experience building and releasing reliable web-based services. If this sounds like you and you are driven by purpose, join SOPHiA GENETICS as a Principal Software Engineer and enable us to make a positive impact on the outcomes for cancer and rare disease patients worldwide.

7 days ago

Operating Principal, Summit PBU Flagship Pioneering, Inc.

Cambridge, MA USA

$220,000–$269,500 / year

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

9 days ago

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Principal Jobs in Waltham, MA

Principal Network Engineer Lila Sciences

Principal DevOps Engineer BitSight Technologies Inc

Associate Principal- Corporate Strategy Advisory Trinity Life Sciences

Principal Scientist, R&D Data, Data Science & Artificial Intelligence - Immunology Johnson & Johnson

Principal Gifts Officer WGBH Boston

Underwriting Principal Fifth Third Bank

Associate Principal Scientist, Clinical Research Merck & Co Inc

Principal Seller McKinstry Co.

Securities & Corporate Counsel (Senior / Principal level considered) Revvity

VP, Principal Resilience Engineer Chubb Ltd

Intelligence Center X Principal - Americas Mendix Technology BV

Principal Game AI Engineer Take-Two Interactive Software Inc

Principal Legal Counsel SS&C Technologies Holdings Inc

Principal Product Designer VIA

Principal DevOps Architect MKS Inc

Principal DevOps Engineer BitSight Technologies

Principal Scientist, Target Binding Generate Biomedicines

Principal Associate Scientist, Analytical Development & Operations Strand Therapeutics Inc

Principal Software Engineer (Sre & Architecture) Sophia Genetics

Operating Principal, Summit PBU Flagship Pioneering, Inc.

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