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Principal Jobs in Watertown, MA

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Principal ML Platform Engineer - Remote Appian Corporation

Boston, MA

Remote

$175,000–$325,000 / year

Growth Opportunities: Appian provides a diverse array of growth and development opportunities, including our leadership program tailored for new and aspiring managers, a comprehensive library of specialized department training through Appian University, skills based training, and tuition reimbursement for those aiming to advance their education. Equipped with cutting-edge AI tooling, you will drive the design and delivery of high-complexity engineering solutions, set the technical bar for the team, and lead other engineers towards solutions of real complexity to ensure flawless Enterprise-Grade Orchestration.

1 day ago

Principal Design Engineer (Mechanical / Mechatronic) System One

Cambridge, MA

Quick Apply

Ten or more years designing precision electromechanical instruments or automated production equipment, with at least five as lead or principal designer on products that reached build and qualification. • Deep practical experience of precision fluid handling: pumps, valves, manifolds, tubing sets, connectors, seals, dead-volume and carryover control.

1 day ago

Principal Program Manager Waters Corporation

Milford, MA

The role serves as the primary business-facing lead for PLM delivery, working closely with stakeholders, IT teams, implementation partners, and senior leaders to ensure PLM capabilities support business priorities, regulatory expectations, operational efficiency, and product data governance. This role combines practical program leadership with strong PLM business process knowledge to deliver scalable solutions across Engineering, Quality, Manufacturing, Regulatory Affairs, Supply Chain, IT, and ERP-connected processes.

1 day ago

Principal Pricing Data Engineer Waters Corporation

Milford, MA

Strong business domain knowledge and experience working with enterprise systems such as SAP (e.g., supply chain data, orders, revenue recognition, pricing), Salesforce (commercial operations), and/or Service Excellence domains, with the ability to translate business processes into scalable data solutions. We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance.

1 day ago

Senior Principal Enterprise Architect Waters Corporation

Milford, MA

As a senior individual contributor with broad influence, the Principal Enterprise Architect will operate at the intersection of business strategy and technology execution—guiding complex architectural decisions, enabling large scale integration programs, and ensuring that near term transformation choices support long term scalability, resilience, and value creation. This role is responsible for shaping Waters’ long term technology direction while playing a critical leadership role in the integration of BD businesses, platforms, and data into the Waters ecosystem.

1 day ago

Research Principal Scientist Waters Corporation

Milford, MA

Design materials with optimized specific applications in reversed-phase, Ion-exchange, HILIC, affinity, mixed-mode, and sample preparation workflows for separations of proteins, monoclonal antibodies, oligonucleotides, peptides, PFAS, and small molecules. Members of Global Research work in highly collaborative cross-functional teams spanning Consumables, Liquid Chromatography, Mass Spectrometry, Clinical, and Informatics technologies to develop novel solutions for complex analytical problems.

1 day ago

Senior Principal Scientist Waters Corporation

Milford, MA

In addition to leading innovation in material design, you will help advance next-generation manufacturing strategies for Waters particle and bonded-phase production, including scalable and data-rich manufacturing approaches, advanced process characterization, and in-process analytical testing methodologies. As a Senior Principal Scientist within the BioSeparations Portfolio of the Chemistry & Lab Automation Business Unit, you will define and lead the scientific strategy for novel chromatographic materials and enabling chemistries for biologics ranging from oligonucleotides, viral vectors, and mRNA to proteins, peptides, and gene-editing therapeutics.

1 day ago

Principal Data Engineer Waters Corporation

Milford, MA

Strong business domain knowledge and experience working with enterprise systems such as SAP (e.g., supply chain data, orders, revenue recognition, pricing), Salesforce (commercial or service processes), with the ability to translate business processes into scalable data solutions. The Principal Data Engineer designs, builds, and enhances robust data pipelines and platforms that support analytics, machine learning, and operational monitoring.

1 day ago

Principal Data Engineer (Service) Waters Corporation

Milford, MA

Design and build scalable, reliable data platforms that integrate service delivery data (work orders, cases, products, geography), service team member data (roles, locations, workloads), service revenue and cost data, and proforma P&L information to enable strategic decision-making. You will bring deep technical expertise in service business data domains, operate with a high degree of independence, and contribute to the design and delivery of scalable data platforms that enable strategic decision-making for revenue growth, margin expansion, and operational excellence initiatives targeting $200M+ in EBIT improvement.

1 day ago

Principal AI Solutions Engineer Waters Corporation

Cambridge, MA

The successful candidate will partner with scientists and engineers across the research organization to identify high-value use cases, configure AI-enabled workflows, and scale approaches that improve productivity, accelerate discovery, and increase innovation yield in domains where AI has not traditionally been applied. Waters Global Research organization advances the analytical instruments, chemistries, and software that laboratories worldwide rely on to characterize molecules with exceptional precision — from biopharmaceuticals to the safety of the food and water supply.

1 day ago

Principal AI Security Analyst Waters Corporation

Milford, MA

We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance. You will lead the security review of AI/ML systems, manage our AI security toolchain, identify emerging threats unique to large-scale models, and build the frameworks that keep our AI infrastructure resilient against adversarial attacks.

1 day ago

Principal Software Engineer - Storage Engine Elastic

Boston, MA

Remote

This globally distributed, fully remote team of experienced engineers develops core storage and query technologies for observability workloads, including improving storage efficiency, advancing ES|QL query processing and performance, and optimizing data layouts for object storage. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

1 day ago

Principal Product Manager - Remote Circle

Boston, MA

Remote

$197,500–$240,833 / year

You will identify the highest-value customer problems and emerging use cases, establish a coherent strategy across custodial, developer-controlled, user-controlled, agentic, institutional custody, and cold-storage wallet models, and translate that strategy into differentiated products that drive customer adoption and business impact. Drive platform investments that accelerate chain expansion, reduce the cost and complexity of launching new wallet use cases, and improve reliability across EVM, non-EVM, hard-fork, and protocol-upgrade workflows.

14 days ago

Principal Software Engineer - Security Elastic

Boston, MA

By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. • You have a solid comprehension of distributed systems security, including node-to-node mutual trust, zero-trust transport, partition tolerance, and cluster state propagation.

1 day ago

Principal Software Engineer - Search Algorithms Elastic

Boston, MA

This is a principal software engineering role that focuses on enhancing the vector similarity search functionality within Elasticsearch, covering the design and implementation of new vector search features, enhancements to existing vector search functionality, and resolving bugs. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

1 day ago

Principal Enterprise Architect Celigo

Boston, MA

$175,000–$200,000 / year

This is a founding role: you will build Celigo’s enterprise architecture practice from scratch, turning a highly federated, ungoverned technology portfolio into a rationalized, outcome-aligned estate. Analyze the full portfolio with AI tools to surface consolidation targets, flag renewal risk before it becomes urgency, and generate the prioritized action lists that drive productive conversations with Finance, Procurement, and domain leads.

18 days ago

Principal Java Engineer - Distributed Systems, Serverless Elastic

Boston, MA

Leveraging your deep distributed systems expertise to design, build, and operate core pieces of our next-generation Serverless Elasticsearch offering, directly impacting the experience of customers worldwide. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

1 day ago

Principal Product Manager, Risk & Fraud - Remote Circle

Boston, MA

Remote

$200,000–$260,000 / year

Define the strategy and roadmap for a risk and fraud platform that supports real-time and asynchronous risk decisions across products and markets that supports crypto- and traditional financial rails, as well as risk-related use cases across onboarding, account linking, and other customer lifecycle events — with a focus on building a user-friendly rules engine and intuitive tooling for risk operators. Build fraud prediction and detection systems from the ground up by defining risk vectors affecting Circle’s product roadmap and executing mitigating controls to address them by integrating party vendor models, and creating iterative feedback loops that learn from past fraudulent behavior.

14 days ago

Principal Product Manager, Arc Consumer - Remote Circle

Boston, MA

Remote

$225,000–$276,667 / year

You’ll own the product strategy and roadmap for Arc’s consumer experience and work across Design, Engineering, Data, and the broader Circle organization to turn powerful onchain capabilities (like privacy and interoperability) into products that feel intuitive, trustworthy, and delightful. Circle’s platform includes the world’s largest regulated stablecoin network anchored by USDC, Circle Payments Network for global money movement, and Arc, an enterprise-grade blockchain designed to become the Economic OS for the internet.

14 days ago

Principal Product Manager, AI Products Komodo Health

Boston, MA

$245,000–$288,000 / year

Across the healthcare ecosystem, we’re helping our clients unlock critical insights to track detailed patient behaviors and treatment patterns, identify gaps in care, address unmet patient needs, and reduce the global burden of disease. Healthcare or regulated data experience (claims, EHR, patient journeys, provider analytics), or a track record of getting fluent fast in a comparably complex data domain like supply chain, energy, or financial data.

1 day ago

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Principal Jobs in Watertown, MA

Principal ML Platform Engineer - Remote Appian Corporation

Principal Design Engineer (Mechanical / Mechatronic) System One

Principal Program Manager Waters Corporation

Principal Pricing Data Engineer Waters Corporation

Senior Principal Enterprise Architect Waters Corporation

Research Principal Scientist Waters Corporation

Senior Principal Scientist Waters Corporation

Principal Data Engineer Waters Corporation

Principal Data Engineer (Service) Waters Corporation

Principal AI Solutions Engineer Waters Corporation

Principal AI Security Analyst Waters Corporation

Principal Software Engineer - Storage Engine Elastic

Principal Product Manager - Remote Circle

Principal Software Engineer - Security Elastic

Principal Software Engineer - Search Algorithms Elastic

Principal Enterprise Architect Celigo

Principal Java Engineer - Distributed Systems, Serverless Elastic

Principal Product Manager, Risk & Fraud - Remote Circle

Principal Product Manager, Arc Consumer - Remote Circle

Principal Product Manager, AI Products Komodo Health

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