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Principal Jobs in Watertown, MA

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Senior Principal Scientist/Principal Scientist, Immune Engagers Novartis AG

Cambridge, MA

$126,000–$234,000 / year

Strong expertise in cancer biology and/or immunology (especially T cell and/or myeloid cell biology).Expertise in tumor immunology, especially T cell mediated anti-tumor activity, tumor-associated myeloid cell biology and immune suppression in the tumor microenvironment (TME).Proficient in immune-cell functional assays and complex immunophenotyping analysis, including integrated in vitro and ex vivo assays as well as multiparameter flow cytometry. The successful candidate will combine cancer-immunology expertise, rigorous decision making and cross-functional leadership to advance programs from target validation toward clinical development and contribute to broader immune-engager strategy.

2 days ago

Manager, Principal Software Engineer - Global Employer Services Technology Deloitte

Boston, MA

$137,700–$261,625 / year

People within our technology group come from a diverse background - they partner with our go-to-market teams and global clients to solve challenging problems and design experiences and products that anticipate what our Deloitte clients will want and solutions that keep them compliant with global and local regulations. Elevate the organization by mentoring senior and staff-level engineers, developing technical leadership in others, and building the practices that let the team scale - while staying open to sharpening your own thinking through architects, quality engineers, and peers.

3 days ago

Principal Network Engineer Lila Sciences

Cambridge, Massachusetts

$171,000–$230,534 / year

As Principal Network Engineer, you will be the senior technical owner of that network: building the in-house engineering capability to design, secure, and scale it, while increasing the value and effectiveness of our managed service provider relationships. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.

5 days ago

Principal Scientist, R&D Data, Data Science & Artificial Intelligence - Immunology Johnson & Johnson

Cambridge, MA

Remote

$117,000–$201,250 / year

All Job Posting Locations: Cambridge, Massachusetts, United States of America, Raritan, New Jersey, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America. To successfully meet these objectives, this individual will work closely with clinical project teams and functional partners across Translational Science, Translational Medicine, Discovery, Late Development, Market Access, Medical Affairs, Data Platforms, Insights & Analytics, and other relevant functions.

7 days ago

Principal DevOps Engineer BitSight Technologies Inc

Boston, MA

Remote

$126,000–$180,000 / year

This range reflects the minimum and maximum target for new hire salaries for the position across all US locations, is based on a full-time work schedule, and is Bitsight's good faith estimate as of the date of this posting. Operate EKS clusters, including capacity planning, node and pod density, graceful shutdown, and access models that give developers the access they need.

7 days ago

Principal Gifts Officer WGBH Boston

Boston, MA

$110,630–$140,600 / year

The successful candidate will be a senior-level relationship builder with credibility in building a high-net worth pipeline for philanthropy They will have a proven record of identifying, qualifying and cultivating high-net-worth prospects, closing complex major and principal gifts, building lasting donor relationships, and partnering effectively with senior leaders, volunteers, and stakeholders to achieve ambitious fundraising goals. Through individual giving, major gifts, planned giving, institutional fundraising, corporate support, membership, and campaign fundraising, the department builds meaningful relationships with donors who share GBH's commitment to journalism, education, culture, and community engagement.

9 days ago

Underwriting Principal Fifth Third Bank

Boston, MA

$96,500–$207,500 / year

Responsible for identifying, assessing and communicating credit risks; performing detailed due diligence and financial analysis; and supporting sound underwriting decisions within established policies and risk appetite, with escalation of complex, sensitive or policy-exception transactions as required. The base salary for this position is reflective of the range of salary levels for all roles within this pay grade across the U.S. Individual salaries within this range will vary based on factors such as role, relevant skillset, relevant experience, education and geographic location.

6 days ago

Associate Principal Scientist, Clinical Research Merck & Co Inc

Boston, MA

$142,400–$224,100 / year

Experience developing, implementing, and managing immunology clinical programs and trials in healthy participants and/or patients to ensure efficient, timely execution against milestones under accelerated timelines; experience with immunology early patient trials (eg, Phase 1b patient trials in rheumatology, dermatology, and/or gastroenterology) preferred. Brief Description of Position: Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients.

10 days ago

Test Architect Principal Cigna

Newton, MA

$151,600–$252,600 / year

Experience with test management and traceability tooling such as Jira with Xray or Zephyr, qTest, or TestRail, and with embedding quality and security gates in CI/CD platforms such as Jenkins, GitHub Actions, GitLab CI, or Harness, alongside scanning tools such as SonarQube, Snyk, or Checkmarx. Set direction for the PBS Test Lead on testing across the existing estate, confirming that regression of current systems, integration across both estates, and client-wave testing produce evidence that holds at the readiness gate.

9 days ago

VP, Principal Resilience Engineer Chubb Ltd

Boston, MA

$158,550–$229,950 / year

Reporting to the Executive Vice President, Global Resilience and Risk Consulting, and working hand-in-hand with the Vice President, Community Resilience, the Principal Resilience Engineer will work across Chubb's risk consulting, underwriting, catastrophe modeling, claims, and analytics teams, as well as with external stakeholders, including property owners, developers, community associations, local governments, and utilities. The Principal Resilience Engineer will help communities understand what to do, help partners implement effective solutions, and help Chubb recognize meaningful risk reduction - supporting safer properties, stronger communities, and the responsible expansion of insurance in catastrophe-exposed markets.

8 days ago

Principal Seller McKinstry Co.

Boston, MA

$153,400–$229,400 / year

The ideal candidate is a high-energy, results-driven sales executive with a proven track record of closing large-scale DER deals, strong industry relationships, and the ability to strategically position McKinstry's solutions in a highly competitive landscape. This role is responsible for sourcing, structuring, and closing high-value DER projects, driving revenue growth, and expanding McKinstry's market share as a designer, builder and operator of DER projects across the eastern US.

7 days ago

Intelligence Center X Principal - Americas Mendix Technology BV

Boston, MA

$197,300–$394,600 / year

You lead the ideation and creation of our most strategic customer engagements - modelling complex domains as enterprise ontologies, designing agents and machine learning that reason over them and act on them, and delivering agentic applications that compel customers to invest in Intelligence Center X with Siemens. Engage executives and strategic partners - build and defend the business case with senior customer stakeholders, mobilize Siemens leadership, and lead strategic partnerships with GSIs, ISVs and hyperscalers.

9 days ago

Principal Legal Counsel SS&C Technologies Holdings Inc

Boston, MA

$160,000–$215,000 / year

More than 23,000 financial services and healthcare organizations, from the world's largest companies to small and mid-market firms, rely on SS&C for expertise, scale, and technology. Prepare and oversee production of various mutual fund, ETF and closed-end fund regulatory filings with the U.S. Securities and Exchange Commission, including registration statements on Form N-1A and Form N-2.

9 days ago

Associate Principal- Corporate Strategy Advisory Trinity Life Sciences

Waltham, Massachusetts

$170,000–$234,000 / year

Trinity’s salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. Associate Principals have unique • opportunities to manage daily client interactions with full oversight over project teams – client management, project management, employee management, budget and financial management, and more.

11 days ago

Principal Game AI Engineer Take-Two Interactive Software Inc

massachusetts, MA

$180,000–$210,000 / year

Subject to those same considerations, the total compensation package for employees in regular roles may also include other elements, including a bonus and/or equity awards, in addition to a full range of medical, financial, and/or other benefits, provided that temporary or intern roles will not be eligible for many of these payments or benefits. Who We Are: Ghost Story Games is a self-publishing game development studio founded by Ken Levine (Creative Director of System Shock 2, Bioshock, and Bioshock Infinite) and former Irrational Games developers.

10 days ago

Principal Product Designer VIA

Somerville, Massachusetts

Remote

$160,000–$190,000 / year

Own end-to-end UX/UI design across VIA's product suite, including AI-native platforms, agentic workflow interfaces, multiplayer and collaborative data environments, and permission-controlled data sharing experiences. Agentic and collaborative workflow experience: You've navigated UX problems where multiple users or multiple agents interact with shared state, and you know how to make those flows feel clear, not chaotic.

10 days ago

Principal Full Stack Software Engineer (Hybrid) Broadridge Financial Solutions Inc

Boston, MA

$175,000–$195,000 / year

We believe that associates do their best when they feel safe, understood, and valued, and we work diligently and collaboratively to ensure Broadridge is a company-and ultimately a community-that recognizes and celebrates everyone's unique perspective. Being a place where exceptionally driven and hardworking people want to work is how we deliver award-winning services to our customers and ultimately build customer value.

10 days ago

Principal DevOps Engineer BitSight Technologies

Boston, Massachusetts

Remote

This range reflects the minimum and maximum target for new hire salaries for the position across all US locations, is based on a full-time work schedule, and is Bitsight’s good faith estimate as of the date of this posting. Operate EKS clusters, including capacity planning, node and pod density, graceful shutdown, and access models that give developers the access they need.

9 days ago

Operating Principal, Summit PBU Flagship Pioneering, Inc.

Cambridge, MA USA

$220,000–$269,500 / year

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

11 days ago

Principal Scientist, Target Binding Generate Biomedicines

Somerville, Massachusetts

The successful candidate will be an established industry expert in quantitative biophysical assay development, particularly for challenging systems such as integral membrane proteins, lipid- associated targets, detergent-solubilized proteins, and multispecific molecules. This individual will provide scientific and strategic leadership for protein–protein interaction, target-binding, and cell-binding measurements across multiple biotherapeutic discovery and development programs.

14 days ago

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Principal Jobs in Watertown, MA

Senior Principal Scientist/Principal Scientist, Immune Engagers Novartis AG

Manager, Principal Software Engineer - Global Employer Services Technology Deloitte

Principal Network Engineer Lila Sciences

Principal Scientist, R&D Data, Data Science & Artificial Intelligence - Immunology Johnson & Johnson

Principal DevOps Engineer BitSight Technologies Inc

Principal Gifts Officer WGBH Boston

Underwriting Principal Fifth Third Bank

Associate Principal Scientist, Clinical Research Merck & Co Inc

Test Architect Principal Cigna

VP, Principal Resilience Engineer Chubb Ltd

Principal Seller McKinstry Co.

Intelligence Center X Principal - Americas Mendix Technology BV

Principal Legal Counsel SS&C Technologies Holdings Inc

Associate Principal- Corporate Strategy Advisory Trinity Life Sciences

Principal Game AI Engineer Take-Two Interactive Software Inc

Principal Product Designer VIA

Principal Full Stack Software Engineer (Hybrid) Broadridge Financial Solutions Inc

Principal DevOps Engineer BitSight Technologies

Operating Principal, Summit PBU Flagship Pioneering, Inc.

Principal Scientist, Target Binding Generate Biomedicines

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