Computational Genomics Senior Research Scientist Vertex PharmaceuticalsComputational Genomics Senior Research ScientistSan Diego, CaliforniaWorking closely with cross-functional disease project teams, you will help shape the development of novel therapies in areas including lung diseases and pain by designing human genetic and genomics studies and translating complex datasets into insights that inform program strategy, target evaluation, biomarker development, and mechanistic understanding. PhD in computational biology, bioinformatics, genomics, human genetics, systems biology, bioengineering, or a related field, with 3+ years of relevant post-doctoral or industry experience; or Master's degree in a related field with 8+ years of relevant industry experience.
External Innovation, Associate Director Vertex PharmaceuticalsExternal Innovation, Associate DirectorBoston, MassachusettsThe Associate Director, External Innovation reports into the Executive Director, External Innovation and Portfolio Operations, and is responsible for conducting scientific, clinical and commercial analysis, monitoring company/technology evolution across the biopharma landscape and contribute to the evaluation ofcollaboration/acquisition opportunities that are aligned with the corporate strategy. As a member of the External Innovation team, you will contribute across phases of evaluation of external opportunities, participate to cross-functional projects with the transactions and alliance management teams, and manage cross-functional relationships to ensure communication and alignment across stakeholders.
Lab Automation Engineer Vertex PharmaceuticalsLab Automation EngineerBoston, MassachusettsWe seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. The Lab Automation Engineer will be a part of a team dedicated to designing, implementing, and validating automation solutions, across various automation platforms (Hamilton/Biomek/etc.), with a moderate degree of supervision.
Gene Therapy Account Management, Associate Director - Southeast territory which includes FL, GA and AL Vertex PharmaceuticalsGene Therapy Account Management, Associate Director - Southeast territory which includes FL, GA and ALBoston, MassachusettsOwn account planning and lead field team coordination to internally drive future account success; facilitates and provides appropriate and timely feedback to Vertex cross functional partners, management and key stakeholders regarding account level business trends, changes in the therapeutic landscape, business issues and opportunities. Build and maintain strong relationships with key stakeholders (e.g., HCPs, C-Suite level personnel, administrators, pharmacists, and care coordinators involved in Gene Therapy delivery key decision makers) at sites of care and referring sites, with the goal of building awareness for Casgevy.
Executive Director, Data & Methods (Data and Computational Sciences) Vertex PharmaceuticalsExecutive Director, Data & Methods (Data and Computational Sciences)Boston, MassachusettsThis leader will set AI and computational strategy that spans the full breadth of modern drug discovery and scientific therapeutic development; and will translate vision into scalable platforms, methods, and tools that serve every modality and measurably speed up discovery and translation, through the development of cutting-edge methods that leverage critical proprietary and public data to drive impact across our global research portfolio. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Human Resources Business Partner Senior Director Vertex PharmaceuticalsHuman Resources Business Partner Senior DirectorBoston, MassachusettsStrategic Workforce Planning: Drive strategies to attract, develop, and retain high-quality technical and leadership talent, proactively closing capability gaps through targeted build/buy/borrow approaches, internal mobility and upskilling/reskilling pathways as roles evolve with AI, and location strategies that expand access to scarce talent while balancing cost, speed, and business needs, supported by focused retention actions for critical roles. Executive Coach and Developer: Elevate leadership and team performance by coaching the senior leaders, designing and facilitating a structured leadership team journeys that strengthens cohesion, decision quality, prioritization, and accountability, and leading rigorous talent reviews and succession planning that build continuity and deepen pipelines for critical roles.
Financial Planning & Analysis Senior Manager Vertex PharmaceuticalsFinancial Planning & Analysis Senior ManagerBoston, MassachusettsLead strategic, cross-functional initiatives across the COFO organization, partnering with Finance, General Ledger Accounting, Technical Accounting, SEC Reporting, Record-to-Report Strategy & Optimization, Procurement, Strategic Sourcing and DTE to drive process excellence and continuous improvement. Provide Finance Risk SME support for the Third-Party Risk Management (TPRM) program, including evaluation of supplier financial health assessments, review of elevated-risk suppliers, and partnership with Procurement to identify, assess and mitigate third-party financial risks.
Stem Cell Senior Research Associate Vertex PharmaceuticalsStem Cell Senior Research AssociateBoston, MassachusettsWe seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. The successful candidate will work in a team setting and be responsible for coordinating production of program-relevant cell types such as stem cell-derived islets (SC-islet) for use across research team projects.
Pain Regional Account Manager (Chicago or Detroit) Vertex PharmaceuticalsPain Regional Account Manager (Chicago or Detroit)The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pain Regional Account Manager (Boston or NYC) Vertex PharmaceuticalsPain Regional Account Manager (Boston or NYC)The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Patient Safety Medical Director Vertex PharmaceuticalsPatient Safety Medical DirectorBoston, MassachusettsDirectly and/or via oversight of direct reports, the role will lead pre-marketing risk assessment, planning for First-In-Human (FIH) studies, safety content of key Modules (SCS, CLO, Labelling) in regulatory authority submissions for approval, including planning, content and execution of Risk Management Plans (RMPs) and/or Risk Evaluation and Mitigation Strategies (REMS) for and post-marketing requirements. The Senior Medical Director, Patient Safety, Disease Area Safety Head (DASH) will lead all safety and benefit-risk related activities for products within the role's Disease-area and/or Franchise, including pre-franchise products from first in-human clinical trials, into and throughout commercialization.
Clinical Development Associate Medical Director-Nephrology Vertex PharmaceuticalsClinical Development Associate Medical Director-NephrologyBoston, MassachusettsParticipates in the preparation of regulatory documents in support of regulatory submissions, including clinical section of INDs and CTAs, IND safety reports and annual reports for assigned trials, responses to regulatory authorities and Ethics Committees/IRBs, and other documents as appropriate. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Principal Analyst, Digital Discoverability & AI Optimization Vertex PharmaceuticalsPrincipal Analyst, Digital Discoverability & AI OptimizationBoston, MassachusettsDefine and lead Vertex’s enterprise strategy for AEO, GEO, and AI-driven digital discoverability to ensure that Vertex brands, products, and scientific content are represented across search and AI answer environments, and identify opportunities to improve visibility and reduce misinformation risk. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Senior Principal AI Engineer Vertex PharmaceuticalsSenior Principal AI EngineerBoston, MassachusettsWorking within the Agentic AI Platform team, this role will focus on delivering production-grade platform services for model integration, prompt and workflow orchestration, evaluation, observability, performance optimization, and agent lifecycle management. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pain Regional Account Manager (Oregon or Washington) Vertex PharmaceuticalsPain Regional Account Manager (Oregon or Washington)The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Territory Account Manager Roles (Central / South Florida) – Join Vertex’s Sales Talent Community Vertex PharmaceuticalsTerritory Account Manager Roles (Central / South Florida) – Join Vertex’s Sales Talent CommunityFloridaWe seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. As Vertex continues to grow, we’re building relationships with talented Territory Account Managers who are excited by strategic selling, complex account management, and meaningful customer partnerships.
Senior Principal AI Platform Engineer, Data & AI Platform Vertex PharmaceuticalsSenior Principal AI Platform Engineer, Data & AI PlatformBoston, MassachusettsWe seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Team Enablement – Act as a technical multiplier by providing reusable architecture patterns, starter kits, and developer-first abstractions to empower teams across Vertex to build and deploy AI solutions effectively.
Enterprise Talent Management Director Vertex PharmaceuticalsEnterprise Talent Management DirectorBoston, MassachusettsThis highly visible role combines strategic thinking, data-driven decision making, and influential partnership to identify and accelerate high-potential talent, strengthen leadership readiness, and build capabilities that fuel growth. Partnering closely with senior leaders, HR Business Partners, and Centers of Excellence, you will drive enterprise talent reviews, succession planning, leadership pipeline development, executive onboarding, and senior leader development.
Senior Manager, Clinical Study Quality Lead Vertex PharmaceuticalsSenior Manager, Clinical Study Quality LeadBoston, MassachusettsRemoteThe Senior Manager, Clinical Study Quality Lead provides study-level quality oversight for assigned clinical trials to help ensure they are conducted in compliance with Good Clinical Practice (GCP), applicable global regulations, study protocols, and Vertex procedures. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Associate Director, Manufacturing Systems & Automation (CGT) Vertex PharmaceuticalsAssociate Director, Manufacturing Systems & Automation (CGT)Boston, MassachusettsWe seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. We are seeking an experienced Associate Director, Manufacturing Systems and Automation – CGT to lead the manufacturing systems and automation team within the Biopharmaceutical Sciences – Cell & Gene Therapy (CGT) Manufacturing and Process Engineering organization.